Genetic and epigenetic variation of the glucocorticoid receptor (NR3C1) in placenta and infant neurobehavior.
Genetic and epigenetic variation of the glucocorticoid receptor (NR3C1) in placenta and infant neurobehavior.
复制标题
DOI：
10.1002/dev.21061
复制
发表时间：
2013-11
影响因子：
2.2
通讯作者：
Lester, Barry
中科院分区：
文献类型：
--
作者：
Bromer, Cailey;Marsit, Carmen J.;Armstrong, David A.;Padbury, James F.;Lester, Barry
宫内环境可以通过改变胎盘组织的表观遗传调节特征来改变胎盘的功能，从而影响发育中的婴儿。基因变异也可能影响婴儿的发育，或者可能改变表观遗传改变与婴儿结局之间的关系。为了检验这种变异与早期婴儿神经发育的关系，我们检测了186例健康新生儿胎盘中糖皮质激素受体基因(NR3C1)启动子和启动子区域常见SNP的DNA甲基化程度。我们将这些分子特征与NICU网络神经行为量表中的具体总结措施联系起来。在控制了基因型和混杂因素后，我们发现NR3C1甲基化与婴儿运动质量(P=0.05)和婴儿注意力(P=0.05)显著相关，并发现甲基化和基因对婴儿注意力得分的潜在交互作用。这些结果表明，遗传易感婴儿胎盘中NR3C1基因的表观遗传改变可能会对神经发育产生影响，这可能会对神经行为和心理健康结果产生终生影响。需要进一步的研究来更准确地定义这些关系，以及表观遗传变化和基因变异对婴儿健康的相互作用。
The intrauterine environment can impact the developing infant by altering the function of the placenta through changes to the epigenetic regulatory features of this tissue. Genetic variation, too, may impact infant development or may modify the relationship between epigenetic alterations and infant outcomes. To examine the association of this variation with early life infant neurodevelopment, we examined the extent of DNA methylation of the glucocorticoid receptor gene (NR3C1) promoter and a common SNP in the promoter region in a series of 186 placentas from healthy newborn infants. We associated these molecular features with specific summary measures from the NICU Network Neurobehavioral Scales. After controlling for genotype and confounders, we identified significant associations of NR3C1 methylation with infant quality of movement (P=0.05) and with infant attention (P=0.05), and a potential interaction between methylation and genotype on infant attention score. These results suggest that epigenetic alteration of the NR3C1 gene in the placentas of genetically susceptible infants can have impacts on neurodevelopment which may have lifelong impact on neurobehavioral and mental health outcomes. Further research is needed to more precisely define these relationships and the interaction between epigenetic alterations and genetic variations on infant health.
登录
查看更多内容
皮质激素受体基因的单核苷酸多态性与青少年标准化社会压力测试的心率和皮质醇反应之间没有关联：TRAILS 研究。
影响因子：
2.6
作者：
Bouma, Esther M. C.;Riese, Harriette;Nolte, Ilja M.;Oosterom, Elvira;Verhulst, Frank C.;Ormel, Johan;Oldehinkel, Albertine J.
通讯作者：
Oldehinkel, Albertine J.
DOI：
10.1111/j.1469-7610.2010.02282.x
发表时间：
2011-04
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Roth TL;Sweatt JD
通讯作者：
Sweatt JD
影响因子：
3.7
作者：
Marsit CJ;Maccani MA;Padbury JF;Lester BM
通讯作者：
Lester BM
DOI：
10.1111/j.1742-7843.2007.00186.x
发表时间：
2008-02-01
影响因子：
3.1
作者：
Hanson, Mark A.;Gluckman, Peter D.
通讯作者：
Gluckman, Peter D.
影响因子：
3.7
作者：
Oberlander, Tim F.;Weinberg, Joanne;Devlin, Angela M.
通讯作者：
Devlin, Angela M.