Annual Research Review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development.
Annual Research Review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development.
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DOI：
10.1111/j.1469-7610.2010.02282.x
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Sweatt JD
中科院分区：
文献类型：
--
作者：
Roth TL;Sweatt JD
早期发育过程中的经历深刻地影响了CNS的发育，从而为以后的精神病理学带来风险或恢复力。发育神经科学领域的工作提供了令人信服的数据，表明基因组的表观遗传标记可能是这一过程的基础。在啮齿类动物中的实验继续表明，发育敏感期的经历会影响几个基因的DNA甲基化模式。这些经验诱导的DNA甲基化模式代表了稳定的表观遗传修饰，在整个生命周期中改变基因转录并促进特定的行为结果。我们讨论了这些发现与人类的相关性，并简要讨论了这些发现在更广泛的背景下的认知和精神疾病。最后，我们讨论了这些意见对未来研究的影响。
Experiences during early development profoundly affect development of the CNS to impart either risk for or resilience to later psychopathology. Work in the developmental neuroscience field is providing compelling data that epigenetic marking of the genome may underlie aspects of this process. Experiments in rodents continue to show that experiences during sensitive periods of development influence DNA methylation patterns of several genes. These experience-induced DNA methylation patterns represent stable epigenetic modifications that alter gene transcription throughout the lifespan and promote specific behavioral outcomes. We discuss the relevance of these findings to humans, and also briefly discuss these findings in the broader contexts of cognition and psychiatric disorder. We conclude by discussing the implications of these observations for future research.
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DOI：
10.1073/pnas.95.9.5335
发表时间：
1998-04-28
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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Meaney, MJ
影响因子：
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