Placental 11-beta hydroxysteroid dehydrogenase methylation is associated with newborn growth and a measure of neurobehavioral outcome.
Placental 11-beta hydroxysteroid dehydrogenase methylation is associated with newborn growth and a measure of neurobehavioral outcome.
复制标题
DOI：
10.1371/journal.pone.0033794
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Lester BM
中科院分区：
文献类型：
--
作者：
Marsit CJ;Maccani MA;Padbury JF;Lester BM
越来越多的证据表明，宫内环境可以通过改变胎盘的功能表观基因组来影响胎儿的神经发育。在胎盘中，HSD11B2基因编码11-β羟基类固醇脱氢酶，负责母体皮质醇的失活，受DNA甲基化调节，已被证明对来自母体环境的应激源敏感。我们研究了185名健康新生儿胎盘中HSD11B2启动子区域DNA甲基化与婴儿和母亲特征之间的关系，以及这种表观遗传变异与NICU网络神经行为量表评估的新生儿神经行为结果之间的关系。控制混杂因素，HSD11B2甲基化程度在出生体重最低的婴儿中最大(P = 0.04)，这种甲基化增加与运动质量评分降低有关(P = 0.04)。这些结果表明，宫内环境中影响出生结果的因素可能与胎盘HSD11B2基因的甲基化有关，这种表观遗传变化反过来又与前瞻性预测的早期神经行为结果相关，这在一定程度上表明了婴儿神经健康的发育起源的机制。
There is growing evidence that the intrauterine environment can impact the neurodevelopment of the fetus through alterations in the functional epigenome of the placenta. In the placenta, the HSD11B2 gene encoding the 11-beta hydroxysteroid dehydrogenase enzyme, which is responsible for the inactivation of maternal cortisol, is regulated by DNA methylation, and has been shown to be susceptible to stressors from the maternal environment. We examined the association between DNA methylation of the HSD11B2 promoter region in the placenta of 185 healthy newborn infants and infant and maternal characteristics, as well as the association between this epigenetic variability and newborn neurobehavioral outcome assessed with the NICU Network Neurobehavioral Scales. Controlling for confounders, HSD11B2 methylation extent is greatest in infants with the lowest birthweights (P = 0.04), and this increasing methylation was associated with reduced scores of quality of movement (P = 0.04). These results suggest that factors in the intrauterine environment which contribute to birth outcome may be associated with placental methylation of the HSD11B2 gene and that this epigenetic alteration is in turn associated with a prospectively predictive early neurobehavioral outcome, suggesting in some part a mechanism for the developmental origins of infant neurological health.
登录
查看更多内容
影响因子：
10.5
作者：
Gale, CR;Martyn, CN
通讯作者：
Martyn, CN
影响因子：
15.9
作者：
Alikhani-Koopaei, R;Fouladkou, F;Frey, BM
通讯作者：
Frey, BM
DOI：
10.2741/e279
发表时间：
2011-01-01
期刊：
Frontiers in bioscience (Elite edition)
影响因子：
--
作者：
Robins JC;Marsit CJ;Padbury JF;Sharma SS
通讯作者：
Sharma SS
影响因子：
5.8
作者：
Murphy, VE;Zakar, T;Clifton, VL
通讯作者：
Clifton, VL
影响因子：
3.7
作者：
Glover, Vivette;Bergman, Kristin;O'Connor, Thomas G.
通讯作者：
O'Connor, Thomas G.