Relationship between symptoms during a gastric emptying study, daily symptoms and quality of life in patients with diabetes mellitus.
Relationship between symptoms during a gastric emptying study, daily symptoms and quality of life in patients with diabetes mellitus.
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DOI：
10.1111/nmo.14154
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发表时间：
2021-12
影响因子：
3.5
通讯作者：
Bharucha AE
中科院分区：
文献类型：
--
作者：
Kuwelker S;Prichard DO;Bailey K;Bharucha AE
胃排空在预测糖尿病和胃肠道症状患者的症状严重程度方面作用有限。我们评估了基于13C-螺旋藻的胃排空呼气试验(GEBT)或核素扫描中记录的症状预测糖尿病患者日常症状严重程度的程度。对149例有不同严重胃肠道症状的糖尿病患者进行了胃排空、胃排空检查(n=38)或胃排空试验(n=111)，以及日常胃肠道症状的评估。胃排空正常、延迟和快速的患者在GEBT中分别为37%、52%和9%，在核素扫描中分别为55%、34%和11%；GEBT和核素扫描之间的差异不显著。分别有58%和21%的患者接受了放射性核素扫描和GEBT(P<；0.0001)，每天的症状都是中等严重或更严重。GEBT期间的症状(46%)和排空障碍(3%)可解释GEBT组每日症状变化的50%。在核素组中，症状可以解释29%的变异，而脑震荡的影响不显著。在GE研究期间报告一个或多个症状比其他症状更严重的患者中，更有可能(OR 3.98，95%CI 2.16，7.33)在日常日记中报告与最严重的症状相同的症状(S)。GEBT期间和核素扫描期间的症状，但不是胃排空，可以预测日常症状的严重程度，并可作为糖尿病患者的生物标记物。
Gastric emptying is of limited utility for predicting the severity of symptoms in patients with diabetes mellitus and gastrointestinal symptoms. We evaluated the extent to which symptoms recorded during a 13C-spirulina-based gastric emptying breath test (GEBT) or scintigraphy predicted the severity of daily symptoms in diabetes mellitus. Gastric emptying, symptoms during a gastric emptying study, either scintigraphy (n=38) or GEBT (n=111), and daily gastrointestinal symptoms were evaluated in 149 patients with diabetes mellitus and variably severe gastrointestinal symptoms. Gastric emptying was normal, delayed, and rapid in 37%, 52%, and 9% measured with the GEBT and 55%, 34%, and 11% of patients measured with scintigraphy; differences between GEBT and scintigraphy were not significant. Daily symptoms were moderately severe or more intense in 58% and 21% of patients undergoing scintigraphy and GEBT (P < 0.0001). Symptoms during the GEBT (46%) and emptying thalf (3%) explained 50% of the variance in daily symptoms in the GEBT group. In the scintigraphy group, symptoms explained 29% of this variance; the thalf was insignificant. Among patients who reported that one or more symptoms were more severe than the others during the GE study, were more likely (OR 3.98, 95% CI 2.16, 7.33) to report the same symptom(s) as being the most severe in the daily diary. Symptoms during a GEBT and to a lesser extent during scintigraphy, but not gastric emptying predict the severity of daily symptoms and may serve as a biomarker in patients with diabetes mellitus.
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影响因子：
3.5
作者：
Camilleri M;Iturrino J;Bharucha AE;Burton D;Shin A;Jeong ID;Zinsmeister AR
通讯作者：
Zinsmeister AR
影响因子：
12.6
作者：
Szarka, Lawrence A.;Camilleri, Michael;Zinsmeister, Alan R.
通讯作者：
Zinsmeister, Alan R.
影响因子：
3.5
作者：
Revicki, D. A.;Camilleri, M.;Parkman, H. P.
通讯作者：
Parkman, H. P.
影响因子：
3.5
作者：
Desai, Anshuman;Low, Phillip A.;Bharucha, Adil E.
通讯作者：
Bharucha, Adil E.
影响因子：
3.2
作者：
Bharucha AE;Camilleri M;Forstrom LA;Zinsmeister AR
通讯作者：
Zinsmeister AR