Relationship between clinical features and gastric emptying disturbances in diabetes mellitus.
Relationship between clinical features and gastric emptying disturbances in diabetes mellitus.
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DOI：
10.1111/j.1365-2265.2008.03351.x
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发表时间：
2009-03
影响因子：
3.2
通讯作者：
Zinsmeister AR
中科院分区：
文献类型：
--
作者：
Bharucha AE;Camilleri M;Forstrom LA;Zinsmeister AR
糖尿病患者胃排空可能延迟或快速。我们试图确定快速、缓慢或正常GE的糖尿病患者的危险因素或相关特征（即糖尿病“表型”）的差异。从一个用闪烁图评估胃肠运输的患者数据库中，我们比较了快速、缓慢和正常GE的糖尿病患者的糖尿病表型。129例患者中，55例（42%）为正常GE， 46例（36%）为延迟GE， 28例（22%）为快速GE。在每个GE类别中，1型和2型糖尿病的人数大致相等。在多变量分析中，体重明显减轻（OR, 2.81; 95% CI, 1.09 - 7.23）和神经病变（OR, 3.60; 95% CI, 1.07 - 12.89）分别是延迟和快速GE的危险因素。与正常GE相比，胰岛素治疗（OR, 0.08; 95% CI, 0.01 - 0.53）与较低的快速GE风险相关。然而，糖尿病“表型”的其他表现或特征（即糖尿病的类型和持续时间、糖化血红蛋白水平和肠外并发症）对区分正常与延迟或快速GE没有帮助。在60%的特异性下，临床特征区分正常和延迟GE的敏感性为73%，区分正常和快速GE的敏感性为80%。糖尿病与快速和缓慢的GE相关。由于糖尿病表型在识别GE紊乱方面的作用有限，因此应在伴有糖尿病和胃肠道症状的患者中评估GE。
Gastric emptying (GE) may be delayed or rapid in diabetes mellitus. We sought to ascertain differences in risk factors or associated features (i.e. diabetic ‘phenotype’) among patients with diabetes who have rapid, slow or normal GE. From a database of patients in whom gastrointestinal transit was assessed by scintigraphy, we compared the diabetic phenotype in diabetic patients with rapid, slow and normal GE. Of 129 patients, 55 (42%) had normal, 46 (36%) had delayed and 28 (22%) patients had rapid GE. In each GE category, there was an approximately equal number of type 1 and type 2 diabetes. In multivariable analyses, significant weight loss (OR, 2·81; 95% CI, 1·09–7·23) and neuropathy (OR, 3·60; 95% CI, 1·007–12·89) were the risk factors for delayed and rapid GE, respectively. Insulin therapy (OR, 0·08; 95% CI, 0·01–0·53) was associated with a lower risk of rapid compared to normal GE. However, other manifestations or characteristics of the diabetes ‘phenotype’ (i.e. type and duration of diabetes, glycosylated haemoglobin levels, and extraintestinal complications) were not useful for discriminating normal from delayed or rapid GE. At a specificity of 60%, clinical features were 73% sensitive for discriminating between normal and delayed GE and 80% sensitive for discriminating normal from rapid GE. Diabetes is associated with slow and rapid GE. Because the diabetic phenotype is of limited utility for identifying disordered GE, GE should be assessed in patients with diabetes and gastrointestinal symptoms.
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影响因子：
12.6
作者：
Camilleri, M;Dubois, D;Revicki, DA
通讯作者：
Revicki, DA
DOI：
10.1152/ajpgi.00317.2007
发表时间：
2007-11-01
影响因子：
4.5
作者：
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通讯作者：
Farrugia, Gianrico
DOI：
10.1073/pnas.88.24.11490
发表时间：
1991-12-01
影响因子：
11.1
作者：
DESAI, KM;ZEMBOWICZ, A;VANE, JR
通讯作者：
VANE, JR
影响因子：
16.2
作者：
Jones, KL;Russo, A;Horowitz, M
通讯作者：
Horowitz, M
影响因子：
8.9
作者：
Charles, F;Phillips, SF;Thomforde, GM
通讯作者：
Thomforde, GM