MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice.

MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice.
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DOI:
10.3389/fnbeh.2018.00201
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发表时间:
2018
影响因子:
3
通讯作者:
Gómez-Gaviro MV
Gómez-Gaviro MV
中科院分区:
医学3区
文献类型:
--
作者:
Bello-Arroyo E;Roque H;Marcos A;Orihuel J;Higuera-Matas A;Desco M;Caiolfa VR;Ambrosio E;Lara-Pezzi E;Gómez-Gaviro MV

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动物行为测试对于了解神经和心理障碍的基础是必不可少的,可以通过不同的方法学和实验模型进行评估。然而,行为测试结果的量化受到手动评估所需的大量时间和自动分析软件的高成本的限制。为了克服这些限制,我们在这里描述了一个新的、开源的ImageJ工具箱,称为鼠标行为分析工具箱(MouBeAT),旨在半自动分析啮齿动物的不同行为测试。这些测试包括开场(OF)、高架迷宫(EPM)、Y-迷宫(YM)和Morris水迷宫(MWM)。在所有行为测试的所有分析参数中,MouBeAT与人工评估显示出高度的相关性,加强了其作为准确分析工具的价值。这个新工具可以在网上免费获得。
Animal behavioral tests are essential to understand the bases of neurologic and psychological disorders, which can be evaluated by different methodological and experimental models. However, the quantification of behavioral tests results is limited by the considerable amount of time needed for manual evaluation and the high costs of automated analysis software. To overcome these limitations, we describe here a new, open source toolbox for ImageJ, called Mouse Behavioral Analysis Toolbox (MouBeAT), designed to analyze different behavioral tests in rodents semi-automatically. These tests include Open Field (OF), Elevated Plus Maze (EPM), Y-maze (YM) test and Morris Water Maze (MWM). MouBeAT showed a high correlation with manual evaluation in all the parameters analyzed for all the behavioral tests, reinforcing its value as an accurate analysis tool. This new tool is freely available online.
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