Use of Ultraviolet Blood Irradiation Against Viral Infections.
Use of Ultraviolet Blood Irradiation Against Viral Infections.
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DOI：
10.1007/s12016-020-08811-8
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发表时间：
2021-04
影响因子：
9.1
通讯作者：
Castelletto S
中科院分区：
文献类型：
--
作者：
Boretti A;Banik B;Castelletto S
紫外线血液照射(UBI)在20世纪30年代和40年代被成功地用于各种疾病。尽管取得了成功，但由于缺乏对详细作用机制的了解，以及抗生素的成就，自20世纪50年代以来逐步停止了UBI的使用。从艾滋病毒/艾滋病到埃博拉、从SARS和MERS到SARS-CoV-2等新型病毒感染的出现，使人们重新关注这一治疗机会。UBI具有复杂的杀毒活性，主要作用于免疫系统的反应。它对淋巴细胞(T细胞和B细胞)、巨噬细胞、单核细胞、树突状细胞、低密度脂蛋白(LDL)和血脂有影响。克诺特技术被应用于细菌感染，如结核病，到病毒感染，如肝炎或流感。更复杂的体外光分离术(ECP)也被应用于T细胞淋巴瘤等血液病。对UBI的进一步研究可能有助于创造一种有用的设备，可能会发现对已知抗病毒药物或疫苗具有抗药性的新型病毒，或者对已知抗生素具有抗药性的细菌。
Ultraviolet blood irradiation (UBI) was used with success in the 1930s and 1940s for a variety of diseases. Despite the success, the lack of understanding of the detailed mechanisms of actions, and the achievements of antibiotics, phased off the use of UBI from the 1950s. The emergence of novel viral infections, from HIV/AIDS to Ebola, from SARS and MERS, and SARS-CoV-2, bring back the attention to this therapeutical opportunity. UBI has a complex virucidal activity, mostly acting on the immune system response. It has effects on lymphocytes (T-cells and B-cells), macrophages, monocytes, dendritic cells, low-density lipoprotein (LDL), and lipids. The Knott technique was applied for bacterial infections such as tuberculosis to viral infections such as hepatitis or influenza. The more complex extracorporeal photopheresis (ECP) is also being applied to hematological cancers such as T-cell lymphomas. Further studies of UBI may help to create a useful device that may find applications for novel viruses that are resistant to known antivirals or vaccines, or also bacteria that are resistant to known antibiotics.
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影响因子：
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