Stem Cells from Dental Pulp: What Epigenetics Can Do with Your Tooth.
Stem Cells from Dental Pulp: What Epigenetics Can Do with Your Tooth.
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DOI：
10.3389/fphys.2017.00999
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发表时间：
2017
影响因子：
4
通讯作者：
Nic-Can GI
中科院分区：
文献类型：
--
作者：
Rodas-Junco BA;Canul-Chan M;Rojas-Herrera RA;De-la-Peña C;Nic-Can GI
成体干细胞能够自我更新并分化为几种特化细胞类型，因此引起了科学的关注。在这种背景下，人牙组织源性间充质干细胞(HDT-MSCs)已经成为修复或再生受损组织的一种可能的解决方案。这些细胞可以从自然替换的乳牙、第三磨牙或其他牙齿组织中分离出来，并显示出自我更新、高增殖率和巨大的多谱系潜力。然而，决定谱系特征的细胞和分子机制在很大程度上仍不清楚。众所周知，细胞命运的改变需要删除现有的转录程序，然后建立新的发育程序以产生新的细胞谱系。越来越多的证据表明染色质的结构构象可以影响细胞的命运。通过这种方式，DNA或组蛋白水平上的可逆化学修饰及其组合可以激活或灭活特定细胞类型的基因序列，从而产生另一种细胞命运。另一方面，miRNAs开始成为建立特定体细胞谱系的可能参与者。在这篇综述中，我们讨论了两个新的和有前途的医学和生物学领域的研究领域，表观遗传学和干细胞，总结了HDT-MSCs的特性，并重点介绍了表观遗传学对细胞分化调控的最新发现。
Adult stem cells have attracted scientific attention because they are able to self-renew and differentiate into several specialized cell types. In this context, human dental tissue-derived mesenchymal stem cells (hDT-MSCs) have emerged as a possible solution for repairing or regenerating damaged tissues. These cells can be isolated from primary teeth that are naturally replaced, third molars, or other dental tissues and exhibit self-renewal, a high proliferative rate and a great multilineage potential. However, the cellular and molecular mechanisms that determine lineage specification are still largely unknown. It is known that a change in cell fate requires the deletion of existing transcriptional programs, followed by the establishment of a new developmental program to give rise to a new cell lineage. Increasing evidence indicates that chromatin structure conformation can influence cell fate. In this way, reversible chemical modifications at the DNA or histone level, and combinations thereof can activate or inactivate cell-type-specific gene sequences, giving rise to an alternative cell fates. On the other hand, miRNAs are starting to emerge as a possible player in establishing particular somatic lineages. In this review, we discuss two new and promising research fields in medicine and biology, epigenetics and stem cells, by summarizing the properties of hDT-MSCs and highlighting the recent findings on epigenetic contributions to the regulation of cellular differentiation.
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影响因子：
5.6
作者：
Duncan HF;Smith AJ;Fleming GJ;Partridge NC;Shimizu E;Moran GP;Cooper PR
通讯作者：
Cooper PR
影响因子：
21.3
作者：
Fan, Zhipeng;Yamaza, Takayoshi;Lee, Janice S.;Yu, Jinhua;Wang, Songlin;Fan, Guoping;Shi, Songtao;Wang, Cun-Yu
通讯作者：
Wang, Cun-Yu
影响因子：
4
作者：
Aurrekoetxea M;Garcia-Gallastegui P;Irastorza I;Luzuriaga J;Uribe-Etxebarria V;Unda F;Ibarretxe G
通讯作者：
Ibarretxe G
影响因子：
3.7
作者：
Duncan, Henry F.;Smith, Anthony J.;Cooper, Paul R.
通讯作者：
Cooper, Paul R.
影响因子：
4.6
作者：
Fernandez-Rebollo E;Mentrup B;Ebert R;Franzen J;Abagnale G;Sieben T;Ostrowska A;Hoffmann P;Roux PF;Rath B;Goodhardt M;Lemaitre JM;Bischof O;Jakob F;Wagner W
通讯作者：
Wagner W