Dietary sources of methylated arsenic species in urine of the United States population, NHANES 2003-2010.

Dietary sources of methylated arsenic species in urine of the United States population, NHANES 2003-2010.
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美国尿液中甲基化砷物种的饮食来源,NHANES,2003-2010。

DOI:
10.1371/journal.pone.0108098
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发表时间:
2014
期刊:
影响因子:
3.7
通讯作者:
Mortensen ME
Mortensen ME
中科院分区:
综合性期刊3区
文献类型:
--
作者:
deCastro BR;Caldwell KL;Jones RL;Blount BC;Pan Y;Ward C;Mortensen ME

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砷是一种普遍存在的元素,与致癌、神经毒性以及对呼吸道、胃肠道、肝脏和皮肤健康的不良影响有关。确定膳食中形态砷的来源:单甲基砷酸(MMA)和二甲基砷酸(DMA)。对2003年至2010年的NHANES(国家健康和营养检查调查)数据(∼8,300名参与者和6岁儿童)的年龄分层样本加权回归分析表征了尿砷种类与美国农业部标准化食品组(24小时饮食召回数据)的额外消耗量之间的关联,并控制了潜在的混杂因素。在所有砷物种中,尿摩尔浓度中位数的年龄层次顺序为6-11岁;成人20-84岁;青少年12-19岁;对于所有年龄层次,排名顺序为DMA和MMA。甲基化砷的尿摩尔浓度中位数范围为0.56~3.52微克分子/摩尔肌酐。从统计上看,尿砷种类的显著增加与以下消费的增加有关:鱼(DMA);水果(DMA,MMA);谷物产品(DMA,MMA);豆类、坚果、种子(DMA,MMA);肉类、家禽(DMA,MMA);大米(DMA,MMA);年糕/饼干(DMA,MMA);以及糖、糖果、饮料(MMA)。对于成年人,大米饮料/牛奶(DMA,MMA)。此外,根据美国(美国)每个食品组的中位数和第90个百分位数的消费量,重点介绍了下列食品组的风险暴露情况:鱼;水果;谷物产品;豆类、坚果、种子;肉类、家禽;以及糖、糖、饮料。在一项具有全国代表性的美国平民非住院人群样本中,鱼(成人)、大米(儿童)和年糕/饼干(青少年)与尿液DMA的关联最大。对于MMA,大米饮料/牛奶(成人)和年糕/饼干(儿童、青少年)具有最大的关联性。
Arsenic is an ubiquitous element linked to carcinogenicity, neurotoxicity, as well as adverse respiratory, gastrointestinal, hepatic, and dermal health effects. Identify dietary sources of speciated arsenic: monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA). Age-stratified, sample-weighted regression of NHANES (National Health and Nutrition Examination Survey) 2003–2010 data (∼8,300 participants ≥6 years old) characterized the association between urinary arsenic species and the additional mass consumed of USDA-standardized food groups (24-hour dietary recall data), controlling for potential confounders. For all arsenic species, the rank-order of age strata for median urinary molar concentration was children 6–11 years > adults 20–84 years > adolescents 12–19 years, and for all age strata, the rank-order was DMA > MMA. Median urinary molar concentrations of methylated arsenic species ranged from 0.56 to 3.52 µmol/mol creatinine. Statistically significant increases in urinary arsenic species were associated with increased consumption of: fish (DMA); fruits (DMA, MMA); grain products (DMA, MMA); legumes, nuts, seeds (DMA); meat, poultry (DMA); rice (DMA, MMA); rice cakes/crackers (DMA, MMA); and sugars, sweets, beverages (MMA). And, for adults, rice beverage/milk (DMA, MMA). In addition, based on US (United States) median and 90th percentile consumption rates of each food group, exposure from the following food groups was highlighted: fish; fruits; grain products; legumes, nuts, seeds; meat, poultry; and sugars, sweets, beverages. In a nationally representative sample of the US civilian, noninstitutionalized population, fish (adults), rice (children), and rice cakes/crackers (adolescents) had the largest associations with urinary DMA. For MMA, rice beverage/milk (adults) and rice cakes/crackers (children, adolescents) had the largest associations.
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