Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow.
Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow.
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DOI：
10.1084/jem.20221717
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发表时间：
2023-02-06
期刊：
影响因子：
--
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作者：
Koike et al.对浆细胞采用时间戳方法，并测量具有不同同型的稳态浆细胞或以生发中心非依赖或依赖途径产生的抗原特异性浆细胞的衰变。浆细胞的寿命取决于它们进入和居住在所谓的壁龛中的能力，这些壁龛主要位于骨髓中。在这里，通过使用可追踪的方法标记最近生成的浆细胞，我们表明骨髓和脾中的稳态浆细胞由新生成的B220hiMHC-IIhi种群不断补充，并逐渐分化为B220loMHC-IIlo长寿命浆细胞(LLPC)种群。我们还发现，在骨髓中，生发中心(GC)不依赖和GC依赖的浆细胞在NP-CGG结合时衰退相似，都进入了B220loMHC-IIlo LLPC池。与NP+B220hiMHC-IIhi浆细胞相比，NP+B220loMHC-IIlo细胞更多地固定在骨髓壁龛中，显示出更好的生存潜力。因此，我们的结果表明，骨髓浆细胞的黏附状态在其分化过程中是动态变化的，并与提供生存信号有关。
Koike et al. employ a time-stamping method for plasma cells and measure the decay of the homeostatic plasma cells with distinct isotypes, or antigen-specific plasma cells that are generated in germinal center–independent or –dependent pathway. The longevity of plasma cells is dependent on their ability to access and reside in so-called niches that are predominantly located in the bone marrow. Here, by employing a traceable method to label recently generated plasma cells, we showed that homeostatic plasma cells in the bone marrow and spleen were continuously replenished by newly generated B220hiMHC-IIhi populations that progressively differentiated into B220loMHC-IIlo long-lived plasma cell (LLPC) populations. We also found that, in the bone marrow, germinal center (GC)–independent and GC-dependent plasma cells decayed similarly upon NP-CGG engagement, and both entered the B220loMHC-IIlo LLPC pool. Compared with NP+B220hiMHC-IIhi plasma cells, NP+B220loMHC-IIlo cells were more immobilized in the bone marrow niches and showed better survival potential. Thus, our results suggest that the adhesion status of bone marrow plasma cells is dynamically altered during their differentiation and is associated with provision of survival signals.
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成熟成骨细胞和破骨细胞之间的直接细胞 - 细胞接触动态控制其在体内的功能。
影响因子：
16.6
作者：
Furuya M;Kikuta J;Fujimori S;Seno S;Maeda H;Shirazaki M;Uenaka M;Mizuno H;Iwamoto Y;Morimoto A;Hashimoto K;Ito T;Isogai Y;Kashii M;Kaito T;Ohba S;Chung UI;Lichtler AC;Kikuchi K;Matsuda H;Yoshikawa H;Ishii M
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Ishii M
DOI：
10.1084/jem.20200866
发表时间：
2021-01-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Inoue T;Shinnakasu R;Kawai C;Ise W;Kawakami E;Sax N;Oki T;Kitamura T;Yamashita K;Fukuyama H;Kurosaki T
通讯作者：
Kurosaki T
影响因子：
7.3
作者：
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通讯作者：
Martins GA
影响因子：
64.5
作者：
Sakaue-Sawano, Asako;Kurokawa, Hiroshi;Miyawaki, Atsushi
通讯作者：
Miyawaki, Atsushi
影响因子：
32.4
作者：
Halliley JL;Tipton CM;Liesveld J;Rosenberg AF;Darce J;Gregoretti IV;Popova L;Kaminiski D;Fucile CF;Albizua I;Kyu S;Chiang KY;Bradley KT;Burack R;Slifka M;Hammarlund E;Wu H;Zhao L;Walsh EE;Falsey AR;Randall TD;Cheung WC;Sanz I;Lee FE
通讯作者：
Lee FE