Fluorescent visualization of oxytocin in the hypothalamo-neurohypophysial system.

Fluorescent visualization of oxytocin in the hypothalamo-neurohypophysial system.
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催产素在下丘脑 - 神经型物理系统中的荧光可视化。

DOI:
10.3389/fnins.2014.00213
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发表时间:
2014
影响因子:
4.3
通讯作者:
Ueta Y
Ueta Y
中科院分区:
医学2区
文献类型:
--
作者:
Hashimoto H;Matsuura T;Ueta Y

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催产素(OXT)因其对乳汁排出反射和子宫收缩的能力而闻名。它还参与其他几种行为,如抗伤害、焦虑、进食、社会认可和压力反应。OXT是在下丘脑室旁核(PVN)和视上核(SON)的大细胞神经分泌细胞(MNCs)中合成的,视上核(SON)终止它们在垂体后叶(PP)的轴突。我们产生了表达oxt和荧光蛋白融合基因的转基因大鼠,以便在下丘脑-神经垂体系统(HNS)中观察oxt。在这些转基因大鼠中,在PP的单核细胞和轴突终末观察到了荧光蛋白。该转基因大鼠为研究OXT在HNS中的生理作用提供了新的工具。
Oxytocin (OXT) is well known for its ability to the milk ejection reflex and uterine contraction. It is also involved in several other behaviors, such as anti-nociception, anxiety, feeding, social recognition, and stress responses. OXT is synthesized in the magnocellular neurosecretory cells (MNCs) in the hypothalamic paraventricular (PVN) and the supraoptic nuclei (SON) that terminate their axons in the posterior pituitary (PP). We generated transgenic rats that express the OXT and fluorescent protein fusion gene in order to visualize OXT in the hypothalamo-neurohypophysial system (HNS). In these transgenic rats, fluorescent proteins were observed in the MNCs and axon terminals in the PP. This transgenic rat is a new tool to study the physiological role of OXT in the HNS.
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发表时间: 2002-07-31
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