Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma.
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma.
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DOI：
10.3322/caac.21626
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Thomas CR Jr
中科院分区：
文献类型：
--
作者：
Grossberg AJ;Chu LC;Deig CR;Fishman EK;Hwang WL;Maitra A;Marks DL;Mehta A;Nabavizadeh N;Simeone DM;Weekes CD;Thomas CR Jr
尽管在外分泌胰腺癌的分子理解方面取得了巨大进展，但这种疾病的预后仍然非常差，主要是由于疾病检测延迟和全身治疗的有效性有限。胰腺癌的发病率和死亡率在过去十年中都有所增加，与大多数其他实体瘤类型形成鲜明对比。最近在多模式护理方面的改进大大提高了适合手术切除的局部肿瘤患者的总生存率、局部控制率和无转移生存率。可切除和不可切除或转移性疾病患者之间的预后差距越来越大，这加强了更早检测胰腺癌以改善预后的重要性。此外，针对肿瘤特异性分子脆弱性的疗法的开发使用可能为晚期疾病患者提供更好的疾病控制。最后，与胰腺癌相关的大量发病率，包括消瘦，疲劳和疼痛，仍然是这种疾病的一个未得到充分解决的组成部分，这有力地影响了生活质量，并限制了对积极治疗的耐受性。在本文中，我们回顾了目前胰腺癌的多学科护理标准，重点是胰腺癌检测，精确治疗和生存率的新兴概念。
Despite tremendous gains in the molecular understanding of exocrine pancreatic cancer, the prognosis for this disease remains very poor, largely owing to delayed disease detection and limited effectiveness of systemic therapies. Incidence rates and mortality rates for pancreatic cancer have both increased during the past decade, in stark contrast to most other solid tumor types. Recent improvements in multimodality care have substantially improved overall survival, local control, and metastasis-free survival for patients with localized tumors amenable to surgical resection. The widening gap in prognosis between patients with resectable and unresectable or metastatic disease reinforces the importance of detecting pancreatic cancer sooner to improve outcomes. Furthermore, the developing use of therapies that target tumor-specific molecular vulnerabilities may offer improved disease control for patients with advanced disease. Finally, the substantial morbidity associated with pancreatic cancer, including wasting, fatigue, and pain, remains an underaddressed component of this disease, which powerfully impacts quality of life and limits tolerance to aggressive therapies. In this paper we review the current multidisciplinary standards of care in pancreatic cancer with a focus on emerging concepts in pancreatic cancer detection, precision therapy, and survivorship.
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影响因子：
29.4
作者：
Apte MV;Wilson JS;Lugea A;Pandol SJ
通讯作者：
Pandol SJ
影响因子：
7.7
作者：
Andersen DK;Korc M;Petersen GM;Eibl G;Li D;Rickels MR;Chari ST;Abbruzzese JL
通讯作者：
Abbruzzese JL
影响因子：
19.7
作者：
Al-Hawary, Mahmoud M.;Francis, Isaac R.;Simeone, Diane M.
通讯作者：
Simeone, Diane M.
影响因子：
3.8
作者：
Babic, Ana;Rosenthal, Michael H.;Wolpin, Brian M.
通讯作者：
Wolpin, Brian M.
DOI：
10.1097/pas.0000000000000533
发表时间：
2015-12
期刊：
The American journal of surgical pathology
影响因子：
--
作者：
Basturk O;Hong SM;Wood LD;Adsay NV;Albores-Saavedra J;Biankin AV;Brosens LA;Fukushima N;Goggins M;Hruban RH;Kato Y;Klimstra DS;Klöppel G;Krasinskas A;Longnecker DS;Matthaei H;Offerhaus GJ;Shimizu M;Takaori K;Terris B;Yachida S;Esposito I;Furukawa T;Baltimore Consensus Meeting
通讯作者：
Baltimore Consensus Meeting