The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis.
The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis.
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在发育，重编程和肿瘤发生过程中，视网膜的动态表观遗传景观。
DOI：
10.1016/j.neuron.2017.04.022
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发表时间：
2017-05-03
期刊：
影响因子：
16.2
通讯作者：
St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project
中科院分区：
文献类型：
--
作者：
Aldiri I;Xu B;Wang L;Chen X;Hiler D;Griffiths L;Valentine M;Shirinifard A;Thiagarajan S;Sablauer A;Barabas ME;Zhang J;Johnson D;Frase S;Zhou X;Easton J;Zhang J;Mardis ER;Wilson RK;Downing JR;Dyer MA;St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project
在发育中的视网膜中，多能神经祖细胞以精确的时空顺序进行单向分化。在这里，我们概况的表观遗传和转录的变化，发生在视网膜发生在小鼠和人类。虽然一些祖细胞基因和细胞周期基因在视网膜发生过程中表观遗传沉默，最引人注目的变化是去抑制细胞类型特异性分化程序。我们确定了发育阶段特异性的超级增强子，并表明大多数表观遗传变化在人类和小鼠中是保守的。为了确定表观基因组在肿瘤发生和重编程过程中如何变化，我们对鼠和人视网膜母细胞瘤以及源自鼠视杆细胞的诱导多能干细胞（iPSC）进行了综合表观遗传学分析。视网膜母细胞瘤表观基因组映射到视网膜祖细胞从神经源性细胞分裂模式转变为终末细胞分裂模式的发育阶段。视网膜母细胞瘤的表观基因组与正常视网膜的表观基因组比视网膜衍生的iPSC更相似，我们鉴定了视网膜特异性表观遗传记忆。
In the developing retina, multipotent neural progenitors undergo unidirectional differentiation in a precise spatiotemporal order. Here we profile the epigenetic and transcriptional changes that occur during retinogenesis in mice and humans. Although some progenitor genes and cell cycle genes were epigenetically silenced during retinogenesis, the most dramatic change was derepression of cell type–specific differentiation programs. We identified developmental stage–specific super-enhancers and showed that most epigenetic changes are conserved in humans and mice. To determine how the epigenome changes during tumorigenesis and reprogramming, we performed integrated epigenetic analysis of murine and human retinoblastomas and induced pluripotent stem cells (iPSCs) derived from murine rod photoreceptors. The retinoblastoma epigenome mapped to the developmental stage when retinal progenitors switch from neurogenic to a terminal patterns of cell division. The epigenome of retinoblastomas was more similar to that of normal retina than was that of retina-derived iPSCs, and we identified retina-specific epigenetic memory.
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影响因子：
64.8
作者：
Heintzman, Nathaniel D.;Hon, Gary C.;Hawkins, R. David;Kheradpour, Pouya;Stark, Alexander;Harp, Lindsey F.;Ye, Zhen;Lee, Leonard K.;Stuart, Rhona K.;Ching, Christina W.;Ching, Keith A.;Antosiewicz-Bourget, Jessica E.;Liu, Hui;Zhang, Xinmin;Green, Roland D.;Lobanenkov, Victor V.;Stewart, Ron;Thomson, James A.;Crawford, Gregory E.;Kellis, Manolis;Ren, Bing
通讯作者：
Ren, Bing
影响因子：
7
作者：
Harrow J;Frankish A;Gonzalez JM;Tapanari E;Diekhans M;Kokocinski F;Aken BL;Barrell D;Zadissa A;Searle S;Barnes I;Bignell A;Boychenko V;Hunt T;Kay M;Mukherjee G;Rajan J;Despacio-Reyes G;Saunders G;Steward C;Harte R;Lin M;Howald C;Tanzer A;Derrien T;Chrast J;Walters N;Balasubramanian S;Pei B;Tress M;Rodriguez JM;Ezkurdia I;van Baren J;Brent M;Haussler D;Kellis M;Valencia A;Reymond A;Gerstein M;Guigó R;Hubbard TJ
通讯作者：
Hubbard TJ
影响因子：
64.5
作者：
Hnisz D;Abraham BJ;Lee TI;Lau A;Saint-André V;Sigova AA;Hoke HA;Young RA
通讯作者：
Young RA
影响因子：
11.2
作者：
Johnson, Dianna A.;Zhang, Jiakun;Dyer, Michael A.
通讯作者：
Dyer, Michael A.
DOI：
10.1073/pnas.0508214103
发表时间：
2006-03-07
影响因子：
11.1
作者：
Akimoto, M;Cheng, H;Swaroop, A
通讯作者：
Swaroop, A