Recent advances in bone tissue engineering scaffolds.
Recent advances in bone tissue engineering scaffolds.
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DOI：
10.1016/j.tibtech.2012.07.005
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发表时间：
2012-10
影响因子：
17.3
通讯作者：
Bandyopadhyay, Amit
中科院分区：
文献类型：
--
作者：
Bose, Susmita;Roy, Mangal;Bandyopadhyay, Amit
关键词：
由于人口中位数年龄的增加，骨疾病是一个值得关注的问题。传统上，骨移植用于修复受损的骨。合成生物材料现在被用作骨移植的替代品。这些生物材料最初是根据其生物力学特性选择用于结构修复的。后来的支架被设计成具有生物活性或生物可吸收性，以促进组织生长。现在支架被设计用来诱导骨形成和血管形成。这些支架通常是多孔的、可生物降解的材料，含有不同的生长因子、药物、基因或干细胞。在这篇综述中，我们重点介绍了骨支架的最新进展，并讨论了仍需改进的方面。
Bone disorders are of significant concern due to increase in the median age of our population. Traditionally, bone grafts have been used to restore damaged bone. Synthetic biomaterials are now being used as bone graft substitutes. These biomaterials were initially selected for structural restoration based on their biomechanical properties. Later scaffolds were engineered to be bioactive or bioresorbable to enhance tissue growth. Now scaffolds are designed to induce bone formation and vascularization. These scaffolds are often porous, biodegradable materials that harbor different growth factors, drugs, genes or stem cells. In this review, we highlight recent advances in bone scaffolds and discuss aspects that still need to be improved.
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