Effect and placental transfer of dexmedetomidine during caesarean section under epidural anaesthesia.
Effect and placental transfer of dexmedetomidine during caesarean section under epidural anaesthesia.
复制标题
DOI：
10.1177/0300060517698330
复制
发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Liu C
中科院分区：
文献类型：
--
作者：
Wang C;Liu S;Han C;Yu M;Hu Y;Liu C
探讨右美托咪定在硬膜外麻醉剖宫产术中的新生儿效应及胎盘转移情况。40名产妇与一个单一的新生儿谁计划剖腹产入组。患者在硬膜外麻醉后10 min接受0.5 µg/kg右美托咪定，然后以0.5 µg/kg/h的速度输注右美托咪定直至腹部闭合（Dex组）或输注生理盐水（NS组）。在输注前（T0）、输注后10 min（T1）、分娩时（T2）和手术结束时（T3）监测收缩压（SBP）、舒张压（DBP）和心率（HR）。收集脐静脉和动脉血。分别于分娩后1 min和5 min进行Apgar评分。与T0相比，Dex组T3时SBP、DBP和HR降低（分别为116 ± 10.4 vs 111 ± 9.2 mmHg，74 ± 6.7 vs 66 ± 7.9 mmHg，91 ± 12.1 vs 71 ± 8.4次/min，P < 0.05）。Dex组T1、T2、T3时HR低于NS组（P < 0.05）。两组血气分析及Apgar评分比较差异无统计学意义（P > 0.05）。右美托咪定用于硬膜外麻醉下剖宫产术对产妇有益。胎盘转移率为0.68。
To investigate the neonatal effect and placental transfer of dexmedetomidine during caesarean section under epidural anaesthesia. Forty parturients with a single newborn who were scheduled for caesarean section were enrolled. Patients received 0.5 µg/kg dexmedetomidine 10 min after epidural anaesthesia, followed by 0.5 µg/kg/h until abdominal closure (Dex group) or infusion of normal saline (NS group). Systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were monitored before infusion (T0), 10 min after infusion (T1), at delivery (T2), and at the end of the operation (T3). Umbilical vein and artery blood was collected. Apgar scores were evaluated at 1 and 5 min after delivery. SBP, DBP, and HR in the Dex group were decreased at T3 compared with T0 (116 ± 10.4 vs 111 ± 9.2 mmHg, 74 ± 6.7 vs 66 ± 7.9 mmHg, 91 ± 12.1 vs 71 ± 8.4 beats/min, respectively, P < 0.05). HR was lower at T1, T2, and T3 in the Dex group compared with the NS group (P < 0.05). There were no significant differences in blood gases and Apgar scores between the groups (P > 0.05). Dexmedetomidine during caesarean section under epidural anaesthesia is beneficial to parturients. The placental transfer rate is 0.68.
登录
查看更多内容
肉毒硬膜外镇痛的患者剖宫产的麻醉算法。
影响因子：
--
作者：
Vaida S;Cattano D;Hurwitz D;Mets B
通讯作者：
Mets B
影响因子：
2.1
作者：
AlaKokko, TI;Pienimaki, P;Vahakangas, K
通讯作者：
Vahakangas, K
影响因子：
3.1
作者：
Yu, Min;Han, Chuanbao;Ding, Zhengnian
通讯作者：
Ding, Zhengnian
影响因子：
2.8
作者：
El-Tahan, M. R.;Mowafi, H. A.;Al-Juhaiman, R. A.
通讯作者：
Al-Juhaiman, R. A.
影响因子：
5.1
作者：
Chrysostomou, Constantinos;Schulman, Scott R.;Gramlich, Lisa
通讯作者：
Gramlich, Lisa