Molecular Action of Polyphenols in Leukaemia and Their Therapeutic Potential.
Molecular Action of Polyphenols in Leukaemia and Their Therapeutic Potential.
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DOI：
10.3390/ijms22063085
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发表时间：
2021-03-17
影响因子：
5.6
通讯作者：
Jordan-Mahy N
中科院分区：
文献类型：
--
作者：
Alaswad HA;Mahbub AA;Le Maitre CL;Jordan-Mahy N
白血病是一种恶性血液病。目前的白血病治疗方法有严重的副作用。植物来源的多酚已被鉴定为有效的抗癌剂，并已被证明与白血病细胞系中的标准化疗剂协同作用。多酚具有多种作用机制，并且已报道通过激活半胱天冬酶（3、8和9）、线粒体膜电位的丧失和细胞色素c的释放来减少细胞增殖、阻止细胞周期和诱导细胞凋亡。多酚已被证明可以抑制转录因子的激活，包括NF-κ B和STAT 3。此外，多酚具有促氧化特性，越来越多的证据表明多酚抑制谷胱甘肽的抗氧化活性，导致氧化性DNA损伤。多酚还诱导自噬驱动的癌细胞死亡并调节多药耐药蛋白，因此可能能够逆转对化疗药物的耐药性。本文综述了多酚类化合物作用的分子机制，并讨论了其潜在的治疗靶点。在这里，我们讨论了多酚的药理学特性，包括它们的抗炎，抗氧化，抗增殖和抗肿瘤活性，并建议多酚是有效的天然药物，可以是有用的治疗;并讨论为什么生物利用度，毒性和代谢的数据是必不可少的，以评估其临床应用。
Leukaemia is a malignant disease of the blood. Current treatments for leukaemia are associated with serious side-effects. Plant-derived polyphenols have been identified as potent anti-cancer agents and have been shown to work synergistically with standard chemotherapy agents in leukaemia cell lines. Polyphenols have multiple mechanisms of action and have been reported to decrease cell proliferation, arrest cell cycle and induce apoptosis via the activation of caspase (3, 8 and 9); the loss of mitochondrial membrane potential and the release of cytochrome c. Polyphenols have been shown to suppress activation of transcription factors, including NF-kB and STAT3. Furthermore, polyphenols have pro-oxidant properties, with increasing evidence that polyphenols inhibit the antioxidant activity of glutathione, causing oxidative DNA damage. Polyphenols also induce autophagy-driven cancer cell death and regulate multidrug resistance proteins, and thus may be able to reverse resistance to chemotherapy agents. This review examines the molecular mechanism of action of polyphenols and discusses their potential therapeutic targets. Here, we discuss the pharmacological properties of polyphenols, including their anti-inflammatory, antioxidant, anti-proliferative, and anti-tumour activities, and suggest that polyphenols are potent natural agents that can be useful therapeutically; and discuss why data on bioavailability, toxicity and metabolism are essential to evaluate their clinical use.
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影响因子：
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发表时间：
2020-01-01
期刊：
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影响因子：
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作者：
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通讯作者：
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作者：
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