Chronic PFOS exposures induce life stage-specific behavioral deficits in adult zebrafish and produce malformation and behavioral deficits in F1 offspring.
Chronic PFOS exposures induce life stage-specific behavioral deficits in adult zebrafish and produce malformation and behavioral deficits in F1 offspring.
复制标题
慢性 PFOS 暴露会导致成年斑马鱼出现生命阶段特定的行为缺陷，并导致 F1 后代出现畸形和行为缺陷
DOI：
10.1002/etc.2031
复制
发表时间：
2013-01
影响因子：
4.1
通讯作者：
Huang, Changjiang
中科院分区：
文献类型：
--
作者：
Chen, Jiangfei;Das, Siba R.;La Du, Jane;Corvi, Margaret M.;Bai, Chenglian;Chen, Yuanhong;Liu, Xiaojuan;Zhu, Guonian;Tanguay, Robert L.;Dong, Qiaoxiang;Huang, Changjiang
全氟辛烷磺酸是一种在环境中普遍存在的有机污染物。很少有研究评估水生生物长期接触全氟辛烷磺酸的行为影响。本研究确定了斑马鱼在不同寿命周期内长期接触全氟辛烷磺酸对行为的影响。具体而言，斑马鱼在受精后1至20天、21至120天或1至120天期间暴露于对照或0.5 µM全氟辛烷磺酸。暴露于PFOS会损害成年斑马鱼在敲击刺激下的行为模式。暴露1 ~ 120 dpf的雌雄鱼在拍打前后的游动速度均显著高于对照组，而暴露120 dpf和21 ~ 120 dpf的组中，只有雄鱼在拍打前游动速度显著提高。结果表明，暴露1 ~ 120 dpf和21 ~ 120 dpf的F1代胚胎中PFOS残留量显著高于对照组，且F1代胚胎畸形率和死亡率均较高。亲鱼的F1代幼鱼暴露于全氟辛烷磺酸1至20或21至120 dpf后，在从亮到暗的行为评估测试中表现出比对照幼鱼更高的游泳速度。与对照组相比，亲鱼暴露于全氟辛烷磺酸1至120 dpf的F1代幼虫在光照期的速度明显降低，而在黑暗期的速度则明显提高。虽然在母体全氟辛烷磺酸暴露1至20 dpf组的胚胎中几乎没有全氟辛烷磺酸残留，但对成虫和F1幼虫的不良行为影响表明，在母体全氟辛烷磺酸暴露前21 dpf期间会导致长期神经行为毒性。作者的研究结果表明，在不同的生命阶段长期接触全氟辛烷磺酸会对成年人的行为和F1后代的形态、行为和生存产生不利影响。Environ.毒理学. 2013;32：201-206。© 2012 SETAC
Perfluorooctane sulfonic acid (PFOS) is an organic contaminant that is ubiquitous in the environment. Few studies have assessed the behavioral effects of chronic PFOS exposure in aquatic organisms. The present study defined the behavioral effects of varying life span chronic exposures to PFOS in zebrafish. Specifically, zebrafish were exposed to control or 0.5 µM PFOS during 1 to 20, 21 to 120, or 1 to 120 d postfertilization (dpf). Exposure to PFOS impaired the adult zebrafish behavior mode under the tapping stimulus. The movement speed of male and female fish exposed for 1 to 120 dpf was significantly increased compared with control before and after tapping, whereas in the groups exposed for 1 to 20 and 21 to 120 dpf, only the males exhibited elevated swim speed before tapping. Residues of PFOS in F1 embryos derived from parental exposure for 1 to 120 and 21 to 120 dpf were significantly higher than control, and F1 embryos in these two groups also showed high malformation and mortality. The F1 larvae of parental fish exposed to PFOS for 1 to 20 or 21 to 120 dpf exhibited a higher swimming speed than control larvae in a light‐to‐dark behavior assessment test. The F1 larvae derived from parental fish exposed to PFOS for 1 to 120 dpf showed a significantly lower speed in the light period and a higher speed in the dark period compared with controls. Although there was little PFOS residue in embryos derived from the 1‐ to 20‐dpf parental PFOS‐exposed group, the adverse behavioral effects on both adult and F1 larvae indicate that exposure during the first 21 dpf induces long‐term neurobehaviorial toxicity. The authors' findings demonstrate that chronic PFOS exposure during different life stages adversely affects adult behavior and F1 offspring morphology, behavior, and survival. Environ. Toxicol. Chem. 2013;32:201–206. © 2012 SETAC
登录
查看更多内容
影响因子：
10.4
作者：
Slotkin TA;MacKillop EA;Melnick RL;Thayer KA;Seidler FJ
通讯作者：
Seidler FJ
DOI：
10.1002/dvdy.22113
发表时间：
2009-12
期刊：
Developmental dynamics : an official publication of the American Association of Anatomists
影响因子：
--
作者：
Parichy DM;Elizondo MR;Mills MG;Gordon TN;Engeszer RE
通讯作者：
Engeszer RE
影响因子：
3.5
作者：
Hurd, MW;Cahill, GM
通讯作者：
Cahill, GM
影响因子：
2.9
作者：
Chen J;Huang C;Zheng L;Simonich M;Bai C;Tanguay R;Dong Q
通讯作者：
Dong Q
影响因子：
2.9
作者：
Eddins, Donnie;Cerutti, Daniel;Williams, Paul;Linney, Elwood;Levin, Edward D.
通讯作者：
Levin, Edward D.