Active agents, biomaterials, and technologies to improve biolubrication and strengthen soft tissues.
Active agents, biomaterials, and technologies to improve biolubrication and strengthen soft tissues.
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DOI：
10.1016/j.biomaterials.2018.07.040
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发表时间：
2018-10
期刊：
影响因子：
14
通讯作者：
Grinstaff MW
中科院分区：
文献类型：
--
作者：
Cooper BG;Catalina Bordeianu;Nazarian A;Snyder BD;Grinstaff MW
从分子到整个生物体的长度尺度上发生的许多生理过程都需要关节组织的正常功能。润滑生物聚合物天然存在于生物关节的各种部位的组织表面上，包括眼睑、口腔和滑膜关节。这些不同界面的操作条件范围产生了多种摩擦学机制，通过这些机制，压缩力和剪切力被消散，以保护组织免受材料磨损和疲劳。本文综述了在疾病和损伤状态下用于治疗性增强摩擦、润滑和磨损的活性剂和生物材料的最新进展。描述了各种小分子、生物和基因递送疗法，以及用天然存在的和合成的生物润滑剂和聚合物增强物进行摩擦补充。虽然重新引入患病组织的天然润滑剂在过去受到了极大的关注，但最近的发现和临床前研究正在利用分子科学和生物工程领域的同步进展，了解潜在的组织结构和生理学，以提供所需的和潜在的患者特异性组织机械响应，用于恢复正常功能。正在研究靶向最近阐明的途径的小分子和大分子药物以及用于恢复所需组织机械反应的合成和混合天然/合成生物材料，用于治疗例如干燥性角膜结膜炎、干皮病和骨关节炎。
Normal functioning of articulating tissues is required for many physiological processes occurring across length scales from the molecular to whole organism. Lubricating biopolymers are present natively on tissue surfaces at various sites of biological articulation, including eyelid, mouth, and synovial joints. The range of operating conditions at these disparate interfaces yields a variety of tribological mechanisms through which compressive and shear forces are dissipated to protect tissues from material wear and fatigue. This review focuses on recent advances in active agents and biomaterials for therapeutic augmentation of friction, lubrication, and wear in disease and injured states. Various small-molecule, biological, and gene delivery therapies are described, as are tribosupplementation with naturally-occurring and synthetic biolubricants and polymer reinforcements. While reintroduction of a diseased tissue’s native lubricant received significant attention in the past, recent discoveries and pre-clinical research are capitalizing on concurrent advances in the molecular sciences and bioengineering fields, with an understanding of the underlying tissue structure and physiology, to afford a desired, and potentially patient-specific, tissue mechanical response for restoration of normal function. Small and large molecule drugs targeting recently elucidated pathways as well as synthetic and hybrid natural/synthetic biomaterials for restoring a desired tissue mechanical response are being investigated for treatment of, for example, keratoconjunctivitis sicca, xeroderma, and osteoarthritis.
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影响因子：
14
作者：
Bodugoz-Senturk, Hatice;Macias, Celia E.;Muratoglu, Orhun K.
通讯作者：
Muratoglu, Orhun K.
影响因子：
158.5
作者：
Clegg, DO;Reda, DJ;Williams, HJ
通讯作者：
Williams, HJ
影响因子：
8
作者：
Borowitz, SM;Cox, DJ;Sutphen, J
通讯作者：
Sutphen, J
DOI：
10.5114/wiitm.2011.34884
发表时间：
2013-12
期刊：
Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques
影响因子：
--
作者：
Banasiewicz T;Horbacka K;Karoń J;Malinger S;Antos F;Rudzki S;Kala Z;Stojcev Z;Kössi J;Krokowicz P
通讯作者：
Krokowicz P
影响因子：
14
作者：
Bodugoz-Senturk, Hatice;Choi, Jeeyoung;Muratoglu, Orhun K.
通讯作者：
Muratoglu, Orhun K.