Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury.
Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury.
复制标题
丘脑的闭环光遗传学控制是在皮质损伤后中断癫痫发作的工具。
DOI：
10.1038/nn.3269
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发表时间：
2013-01
影响因子：
25
通讯作者：
Huguenard, John R.
中科院分区：
文献类型：
--
作者：
Paz, Jeanne T.;Davidson, Thomas J.;Frechette, Eric S.;Delord, Bruno;Parada, Isabel;Peng, Kathy;Deisseroth, Karl;Huguenard, John R.
Cerebrocortical injuries, such as stroke, are a major source of disability. Maladaptive consequences can result from post-injury local reorganization of cortical circuits. For example, epilepsy is a common sequela of cortical stroke, yet mechanisms responsible for seizures following cortical injuries remain unknown. In addition to local reorganization, long-range, extra-cortical connections might be critical for seizure maintenance. Here we report in rats the first evidence that the thalamus – a structure remote from but connected to the injured cortex – is required to maintain cortical seizures. Thalamocortical neurons connected to the injured epileptic cortex undergo changes in HCN channel expression and become hyperexcitable. Targeting these neurons with a closed-loop optogenetic strategy demonstrates that reducing their activity in real-time is sufficient to immediately interrupt electrographic and behavioral seizures. This approach is of therapeutic interest for intractable epilepsy, since it spares cortical function between seizures, in contrast to existing treatments such as surgical lesioning or drugs.
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DOI：
10.1523/jneurosci.5083-09.2010
发表时间：
2010-04-14
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Paz JT;Christian CA;Parada I;Prince DA;Huguenard JR
通讯作者：
Huguenard JR
影响因子：
3.3
作者：
Karhunen, H.;Bezvenyuk, Z.;Pitkanen, A.
通讯作者：
Pitkanen, A.
影响因子：
3.6
作者：
Kelly, Kevin M
通讯作者：
Kelly, Kevin M
影响因子：
1.7
作者：
Lee, Jiun-Chang;Lin, Kuang-Lin;Wong, Alex Mun-Ching
通讯作者：
Wong, Alex Mun-Ching
影响因子：
3
作者：
HORIKAWA, K;ARMSTRONG, WE
通讯作者：
ARMSTRONG, WE