Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions.
Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions.
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DOI：
10.1016/j.chembiol.2017.11.009
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发表时间：
2018-02-15
影响因子：
8.6
通讯作者：
Aittokallio T
中科院分区：
文献类型：
--
作者：
Tang J;Tanoli ZU;Ravikumar B;Alam Z;Rebane A;Vähä-Koskela M;Peddinti G;van Adrichem AJ;Wakkinen J;Jaiswal A;Karjalainen E;Gautam P;He L;Parri E;Khan S;Gupta A;Ali M;Yetukuri L;Gustavsson AL;Seashore-Ludlow B;Hersey A;Leach AR;Overington JP;Repasky G;Wennerberg K;Aittokallio T
了解生物活性物质、获批药物和研究药物以及化学探针的完整靶向空间，可为了解治疗潜力和可能的不良反应提供重要见解。由于非标准化和异质性测定类型以及终点测量的可变性，现有的化合物靶生物活性数据资源通常是不可比较的。为了从现有和未来的化合物靶向分析数据中提取更高的价值，我们实现了一个开放数据网络平台，名为Drug Target Commons（DTC），该平台具有用于众包化合物靶向生物活性数据注释，标准化，策展和资源内整合的工具。我们通过与药物发现和药物再利用应用相关的几个例子展示了DTC的独特价值，并邀请研究人员加入这一社区努力，以增加化合物生物活性数据的重复使用和扩展。DTC是一个基于众包的网络平台，用于注释药物靶点生物活性数据。开放的环境改善了药物再利用应用的数据协调。DTC提供了一个全面的、可重复的和可持续的生物活性知识库。推出了一种新颖的众包努力，以标准化收集，管理，策展和注释的臭名昭著的异构化合物目标生物活性测量。基于网络的社区平台旨在为最终用户提供最全面，可复制和可持续的生物活性知识库。
Knowledge of the full target space of bioactive substances, approved and investigational drugs as well as chemical probes, provides important insights into therapeutic potential and possible adverse effects. The existing compound-target bioactivity data resources are often incomparable due to non-standardized and heterogeneous assay types and variability in endpoint measurements. To extract higher value from the existing and future compound target-profiling data, we implemented an open-data web platform, named Drug Target Commons (DTC), which features tools for crowd-sourced compound-target bioactivity data annotation, standardization, curation, and intra-resource integration. We demonstrate the unique value of DTC with several examples related to both drug discovery and drug repurposing applications and invite researchers to join this community effort to increase the reuse and extension of compound bioactivity data. DTC is a crowd-sourcing-based web platform to annotate drug-target bioactivity data The open environment improves data harmonization for drug repurposing applications DTC offers a comprehensive, reproducible, and sustainable bioactivity knowledge base Tang et al. launches a novel crowd-sourcing effort to standardize the collection, management, curation, and annotation of the notoriously heterogeneous compound-target bioactivity measurements. The web-based community platform aims to provide the most comprehensive, reproducible, and sustainable bioactivity knowledge base for the end users.
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影响因子：
14.8
作者：
Arrowsmith CH;Audia JE;Austin C;Baell J;Bennett J;Blagg J;Bountra C;Brennan PE;Brown PJ;Bunnage ME;Buser-Doepner C;Campbell RM;Carter AJ;Cohen P;Copeland RA;Cravatt B;Dahlin JL;Dhanak D;Edwards AM;Frederiksen M;Frye SV;Gray N;Grimshaw CE;Hepworth D;Howe T;Huber KV;Jin J;Knapp S;Kotz JD;Kruger RG;Lowe D;Mader MM;Marsden B;Mueller-Fahrnow A;Müller S;O'Hagan RC;Overington JP;Owen DR;Rosenberg SH;Roth B;Ross R;Schapira M;Schreiber SL;Shoichet B;Sundström M;Superti-Furga G;Taunton J;Toledo-Sherman L;Walpole C;Walters MA;Willson TM;Workman P;Young RN;Zuercher WJ
通讯作者：
Zuercher WJ
影响因子：
14.8
作者：
Knapp, Stefan;Arruda, Paulo;Zuercher, William J.
通讯作者：
Zuercher, William J.
DOI：
10.1038/nrd.2016.230
发表时间：
2017-01
期刊：
Nature reviews. Drug discovery
影响因子：
--
作者：
Santos R;Ursu O;Gaulton A;Bento AP;Donadi RS;Bologa CG;Karlsson A;Al-Lazikani B;Hersey A;Oprea TI;Overington JP
通讯作者：
Overington JP
影响因子：
28.2
作者：
Dienstmann R;Jang IS;Bot B;Friend S;Guinney J
通讯作者：
Guinney J
影响因子：
1.9
作者：
Abeyruwan S;Vempati UD;Küçük-McGinty H;Visser U;Koleti A;Mir A;Sakurai K;Chung C;Bittker JA;Clemons PA;Brudz S;Siripala A;Morales AJ;Romacker M;Twomey D;Bureeva S;Lemmon V;Schürer SC
通讯作者：
Schürer SC