Inappropriate usage of the Brunner-Munzel test in recent voxel-based lesion-symptom mapping studies.

Inappropriate usage of the Brunner-Munzel test in recent voxel-based lesion-symptom mapping studies.
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DOI:
10.1016/j.neuropsychologia.2009.09.016
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发表时间:
2010-01
期刊:
影响因子:
2.6
通讯作者:
Coslett HB
Coslett HB
中科院分区:
心理学3区
文献类型:
--
作者:
Medina J;Kimberg DY;Chatterjee A;Coslett HB

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基于体素的损伤症状映射(VLSM)技术在阐明人脑结构-功能关系方面具有重要意义。引入了非参数Brunner-Munzel秩序检验,作为VLSM分析中常用的参数检验的替代方法。然而,Brunner-Munzel统计在任何体素(病变组或无病变组中受试者少于10人)处使用时会产生膨胀的z评分。不幸的是,一些最近发表的VLSM研究使用此统计包括相对较小的患者人群,使得大多数(如果不是全部)检查的体素不符合必要的标准。我们证明了不适当使用的Brunner-Munzel测试使用的数据集包括与MRIcron的影响,并找到大的I型错误。为了纠正这一点,我们建议研究人员在使用Brunner-Munzel检验时使用当前版本的MRIcron中实施的置换衍生校正。
Voxel-based lesion symptom mapping (VLSM) techniques have been important in elucidating structure-function relationships in the human brain. introduced the nonparametric Brunner-Munzel rank order test as an alternative to parametric tests often used in VLSM analyses. However, the Brunner-Munzel statistic produces inflated z scores when used at any voxel where there are less than ten subjects in either the lesion or no lesion groups. Unfortunately, a number of recently published VLSM studies using this statistic include relatively small patient populations, such that most (if not all) examined voxels do not meet the necessary criteria. We demonstrate the effects of inappropriate usage of the Brunner-Munzel test using a dataset included with MRIcron, and find large Type I errors. To correct for this we suggest that researchers use a permutation-derived correction as implemented in current versions of MRIcron when using the Brunner-Munzel test.
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