Multiecho water-fat separation and simultaneous R2* estimation with multifrequency fat spectrum modeling.
Multiecho water-fat separation and simultaneous R2* estimation with multifrequency fat spectrum modeling.
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DOI：
10.1002/mrm.21737
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发表时间：
2008-11
影响因子：
3.3
通讯作者：
Reeder, Scott B.
中科院分区：
文献类型：
--
作者：
Yu, Huanzhou;Shimakawa, Ann;McKenzie, Charles A.;Brodsky, Ethan;Brittain, Jean H.;Reeder, Scott B.
关键词：
基于多回波化学位移的水-脂肪分离方法由于其估计和校正场不均匀性的能力而被越来越多地临床使用。先前的基于化学位移的水-脂肪分离方法使用了相对简单的信号模型，该模型假设水和脂肪都具有单个谐振频率。然而，众所周知，脂肪具有多个光谱峰。信号模型中的这种不准确性导致两种不期望的效应。首先，水和脂肪没有完全分离。其次，设计用于在脂肪存在下估计T2* 的方法错误地估计了含有脂肪的组织中的T2* 衰减。在这项工作中，一个更准确的多频率模型的脂肪是包括在理想的水脂肪分离和同时T2* 估计技术。可以假设脂肪谱在所有受试者中是恒定的，并且使用MR光谱法先验地测量。或者，可以使用新颖的光谱自校准算法从数据直接估计脂肪光谱。水脂分离和T2* 估计的改进在各种体内应用中得到证实，包括膝关节、踝关节、脊柱、乳房和腹部扫描。
Multi-echo chemical shift based water-fat separation methods are seeing increasing clinical use due to their ability to estimate and correct for field inhomogeneities. Previous chemical-shift based water-fat separation methods have used a relatively simple signal model that assumes both water and fat have a single resonant frequency. However, it is well known that fat has several spectral peaks. This inaccuracy in the signal model results in two undesired effects. First, water and fat are incompletely separated. Second, methods designed to estimate T2* in the presence of fat incorrectly estimate the T2* decay in tissues containing fat. In this work, a more accurate multi-frequency model of fat is included in the IDEAL water-fat separation and simultaneous T2* estimation techniques. The fat spectrum can be assumed to be constant in all subjects and measured a priori using MR spectroscopy. Alternatively, the fat spectrum can be estimated directly from the data using novel spectrum self-calibration algorithms. The improvement in water-fat separation and T2* estimation is demonstrated in a variety of in-vivo applications, including knee, ankle, spine, breast and abdominal scans.
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