Duration-dependent effects of the BDNF Val66Met polymorphism on anodal tDCS induced motor cortex plasticity in older adults: a group and individual perspective.
Duration-dependent effects of the BDNF Val66Met polymorphism on anodal tDCS induced motor cortex plasticity in older adults: a group and individual perspective.
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DOI：
10.3389/fnagi.2015.00107
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发表时间：
2015
影响因子：
4.8
通讯作者：
Summers JJ
中科院分区：
文献类型：
--
作者：
Puri R;Hinder MR;Fujiyama H;Gomez R;Carson RG;Summers JJ
脑源性神经营养因子（brain derived neurotrophic factor，BDNF）Val 66 Met基因多态性和刺激持续时间被认为在无创性脑刺激（non-invasive brain stimulation，NBS）诱导的运动皮层可塑性调节中起重要作用。在本研究中，我们试图确定这些因素是否相互作用或发挥独立的影响，在老年人。54名健康老年人（平均年龄= 66.85岁）进行了两次1.5 mA阳极经颅直流电刺激（atDCS）的平衡会议，应用于左侧M1为10或20分钟。单脉冲经颅磁刺激（TMS）被用来评估皮质脊髓兴奋性（CSE）之前，每5分钟为30分钟后atDCS。在组水平上，刺激持续时间和BDNF基因型之间存在相互作用，与Val 66 Val纯合子纯合子（n = 37）相比，Met携带者（n = 13）在刺激20分钟（p = 0.002）而不是10分钟（p = 0.219）后显示出更大的干预后CSE增强。此外，Met携带者，而不是瓦尔/瓦尔纯合子，在DCS 20分钟后比在DCS 10分钟后对TMS表现出更大的反应（p = 0.046）。在个体水平上，两步聚类分析显示了相当程度的个体间变异性，总样本的一半以下（42%）显示了CSE在两次治疗中对atDCS的预期增强。对不同atDCS持续时间的反应的个体内变异性也很明显，总样本的三分之一（34%）在一个疗程中表现出LTP样效应，但在另一个疗程中表现出LTD样效应。个体间（p = 0.027）和个体内（p = 0.04）变异性均与BDNF基因型相关。在老年人中，BDNF Val 66 Met多态性沿着刺激持续时间似乎在调节tDCS诱导的运动皮层可塑性中发挥作用。研究结果可能对健康和患病老年人群的NBS协议的设计具有启示意义。
The brain derived neurotrophic factor (BDNF) Val66Met polymorphism and stimulation duration are thought to play an important role in modulating motor cortex plasticity induced by non-invasive brain stimulation (NBS). In the present study we sought to determine whether these factors interact or exert independent effects in older adults. Fifty-four healthy older adults (mean age = 66.85 years) underwent two counterbalanced sessions of 1.5 mA anodal transcranial direct current stimulation (atDCS), applied over left M1 for either 10 or 20 min. Single pulse transcranial magnetic stimulation (TMS) was used to assess corticospinal excitability (CSE) before and every 5 min for 30 min following atDCS. On a group level, there was an interaction between stimulation duration and BDNF genotype, with Met carriers (n = 13) showing greater post-intervention potentiation of CSE compared to Val66Val homozygotes homozygotes (n = 37) following 20 min (p = 0.002) but not 10 min (p = 0.219) of stimulation. Moreover, Met carriers, but not Val/Val homozygotes, exhibited larger responses to TMS (p = 0.046) after 20 min atDCS, than following 10 min atDCS. On an individual level, two-step cluster analysis revealed a considerable degree of inter-individual variability, with under half of the total sample (42%) showing the expected potentiation of CSE in response to atDCS across both sessions. Intra-individual variability in response to different durations of atDCS was also apparent, with one-third of the total sample (34%) exhibiting LTP-like effects in one session but LTD-like effects in the other session. Both the inter-individual (p = 0.027) and intra-individual (p = 0.04) variability was associated with BDNF genotype. In older adults, the BDNF Val66Met polymorphism along with stimulation duration appears to play a role in modulating tDCS-induced motor cortex plasticity. The results may have implications for the design of NBS protocols for healthy and diseased aged populations.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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通讯作者：
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