A nitric oxide-responsive quorum sensing circuit in Vibrio harveyi regulates flagella production and biofilm formation.
A nitric oxide-responsive quorum sensing circuit in Vibrio harveyi regulates flagella production and biofilm formation.
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DOI：
10.3390/ijms140816473
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发表时间：
2013-08-08
影响因子：
5.6
通讯作者：
Boon EM
中科院分区：
文献类型：
--
作者：
Henares BM;Xu Y;Boon EM
细胞信号传导在细菌菌落的存活中起着重要作用。他们使用小分子以细胞密度依赖的方式协调基因表达。这个过程被称为群体感应，帮助细菌调节多种功能，如生物发光，生物膜形成和毒力。在哈氏弧菌，一种生物发光的海洋细菌，四个平行的群体感应系统已被确定为调节光的产生。我们以前曾报道过，一氧化氮（NO），通过H-NOX/HqsK群体感应途径有助于通过LuxU/LuxO/LuxR群体感应途径在哈维氏弧菌的光产生。在这项研究中，我们表明，一氧化氮（NO）也调节鞭毛的生产，提高生物膜的形成。我们的数据表明，哈维氏弧菌能够在不同的生活方式之间切换，以适应环境的变化。
Cell signaling plays an important role in the survival of bacterial colonies. They use small molecules to coordinate gene expression in a cell density dependent manner. This process, known as quorum sensing, helps bacteria regulate diverse functions such as bioluminescence, biofilm formation and virulence. In Vibrio harveyi, a bioluminescent marine bacterium, four parallel quorum-sensing systems have been identified to regulate light production. We have previously reported that nitric oxide (NO), through the H-NOX/HqsK quorum sensing pathway contributes to light production in V. harveyi through the LuxU/LuxO/LuxR quorum sensing pathway. In this study, we show that nitric oxide (NO) also regulates flagellar production and enhances biofilm formation. Our data suggest that V. harveyi is capable of switching between lifestyles to be able to adapt to changes in the environment.
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影响因子：
3.6
作者：
Pratt, LA;Kolter, R
通讯作者：
Kolter, R
影响因子：
3.2
作者：
Lupp, C;Ruby, EG
通讯作者：
Ruby, EG
影响因子：
3.6
作者：
Freeman, JA;Bassler, BL
通讯作者：
Bassler, BL
影响因子：
3.6
作者：
BASSLER, BL;WRIGHT, M;SILVERMAN, MR
通讯作者：
SILVERMAN, MR
影响因子：
3.7
作者：
Bjarnsholt T;Jensen PØ;Jakobsen TH;Phipps R;Nielsen AK;Rybtke MT;Tolker-Nielsen T;Givskov M;Høiby N;Ciofu O;Scandinavian Cystic Fibrosis Study Consortium
通讯作者：
Scandinavian Cystic Fibrosis Study Consortium