Disrupted directed connectivity along the cingulate cortex determines vigilance after sleep deprivation.
Disrupted directed connectivity along the cingulate cortex determines vigilance after sleep deprivation.
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DOI：
10.1016/j.neuroimage.2013.04.103
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发表时间：
2013-10-01
期刊：
影响因子：
5.7
通讯作者：
Van Someren, Eus J. W.
中科院分区：
文献类型：
--
作者：
Piantoni, Giovanni;Cheung, Bing Leung P.;Van Veen, Barry D.;Romeijn, Nico;Riedner, Brady A.;Tononi, Giulio;Van der Werf, Ysbrand D.;Van Someren, Eus J. W.
扣带皮层被认为是大脑结构和功能连接的支柱。虽然它的功能连接已被深入研究，但对其有效连接，行为状态的调制及其参与认知表现知之甚少。鉴于他们以前报道的影响扣带功能连接，我们研究了如何闭眼和睡眠剥夺改变扣带有效连接，估计从静息态高密度脑电图（EEG）使用一种新的方法来计算格兰杰因果关系直接在源空间。有效连接沿着扣带皮层是占主导地位的向前方向。在休息良好的参与者中，与闭眼相比，睁眼向前方向的连接性更大。睁眼和闭眼连通性之间的差异减弱，睡眠剥夺后不再显着。睡眠剥夺后前向连接的个体差异预测了随后的任务表现，例如那些在睁眼和闭眼期间前向连接增加更大的受试者在持续注意力任务中也表现得更好。相反方向的有效连接不受眼睛是睁着还是闭着或睡眠剥夺的影响。这些发现表明，有效的连接从后到前扣带区域增强时，休息良好的主题有他的眼睛打开时，他们关闭。睡眠剥夺会损害这种定向信息流，与其对警惕性的有害影响成正比。因此，睡眠可能在维持清醒时的有效连接方面发挥作用。
The cingulate cortex is regarded as the backbone of structural and functional connectivity of the brain. While its functional connectivity has been intensively studied, little is known about its effective connectivity, its modulation by behavioral states, and its involvement in cognitive performance. Given their previously reported effects on cingulate functional connectivity, we investigated how eye-closure and sleep deprivation changed cingulate effective connectivity, estimated from resting-state high-density electroencephalography (EEG) using a novel method to calculate Granger Causality directly in source space. Effective connectivity along the cingulate cortex was dominant in the forward direction. Eyes-open connectivity in the forward direction was greater compared to eyes-closed, in well-rested participants. The difference between eyes-open and eyes-closed connectivity was attenuated and no longer significant after sleep deprivation. Individual variability in the forward connectivity after sleep deprivation predicted subsequent task performance, such that those subjects who showed a greater increase in forward connectivity between the eyes-open and the eyes-closed periods also performed better on a sustained attention task. Effective connectivity in the opposite, backward, direction was not affected by whether the eyes were open or closed or by sleep deprivation. These findings indicate that the effective connectivity from posterior to anterior cingulate regions is enhanced when a well-rested subject has his eyes open compared to when they are closed. Sleep deprivation impairs this directed information flow, proportional to its deleterious effect on vigilance. Therefore, sleep may play a role in the maintenance of waking effective connectivity.
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影响因子：
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