Same clock, different time read-out: Spontaneous brain oscillations and their relationship to deficient coding of cognitive content
Same clock, different time read-out: Spontaneous brain oscillations and their relationship to deficient coding of cognitive content
复制标题
相同的时钟，不同的时间读数：自发的大脑振荡及其与认知内容编码缺陷的关系
DOI：
10.1016/j.neuroimage.2015.06.071
复制
发表时间：
2015
期刊：
影响因子：
5.7
通讯作者：
Popova
中科院分区：
文献类型：
--
作者：
Popova
神经元振荡提供了一种有效的通信手段，促进支持动作和反应的功能性神经状态。在行动层次中，认知能力在精神分裂症等神经精神疾病中严重受损。目前的想法突出了一个时钟机制提供的一个正在进行的缓慢振荡的阶段，提供了一个时间框架编码的感知和计算元素。然而，不清楚是否以及如何失调的时钟机制解释认知性能下降。在58名健康人（HC）和46名精神分裂症患者（SZ）中，神经磁振荡活动与MATRICS共识认知成套测验评估的认知表现相关。HC显示伽马波段振荡（> 40 Hz）与工作记忆表现之间存在相关性。这种关系在深圳以几种方式被打破。首先，患者表现出较低的伽马功率，较差的工作记忆表现，这些措施之间没有关系。其次，功率谱主要由~ 10 Hz α振荡主导，振幅无组间差异。然而，相位-振幅耦合（PAC）的分析显示，SZ的α相位对γ活动的计时过度，与工作记忆表现不佳相关。第三，尽管夹带由相同的10 Hz时钟，伽玛振幅分布异常的占空比在SZ，受损的中间神经元抑制的潜在后果。第四，SZ表现出过度参与的额顶叶网络测量的伽玛相位coherence，表明大脑状态阻碍cognitive output.Such一个内源性的时间组织可能是一个核心功能障碍在SZ：隔离/整合输入的不平衡促进降低认知性能和妥协的行为输出。
Neuronal oscillations provide an efficient means of communication, fostering functional neural states supporting action and reaction. High in the action hierarchy, cognitive abilities are severely compromised in neuropsychiatric disease such as schizophrenia. Current thinking highlights a clocking mechanism provided by the phase of an ongoing slow oscillation that offers a temporal frame for coding of perceptual and computational elements. Yet unclear is whether and how a dysregulated clocking mechanism accounts for diminished cognitive performance. Neuromagnetic oscillatory activity was related to cognitive performance assessed by the MATRICS Consensus Cognitive Battery in 58 healthy individuals (HC) and 46 schizophrenia patients (SZ). HC showed a correlation between gamma-band oscillations (> 40 Hz) and working memory performance. This relationship was disrupted in several ways in SZ. First, patients evidenced lower gamma power, poorer working memory performance, and no relationship between these measures. Second, the power spectra were dominated by ~ 10 Hz alpha oscillations with no group differences in amplitude. However, analysis of phase-to-amplitude coupling (PAC) revealed exaggerated clocking of gamma activity by alpha phase in SZ, associated with poor working memory performance. Third, despite entrainment by the same 10 Hz clock, gamma amplitude was abnormally distributed across the duty cycle in SZ, a potential consequence of compromised interneuron inhibition. Fourth, SZ showed over-engagement of a fronto-parietal network measured by gamma phase coherence, suggesting a brain state hindering cognitive output.Such an endogenous temporal organization may be a core dysfunction in SZ: a segregation/integration input imbalance fostering reduced cognitive performance and compromised behavioral output.
登录
查看更多内容
影响因子：
9.8
作者：
Szczepanski SM;Crone NE;Kuperman RA;Auguste KI;Parvizi J;Knight RT
通讯作者：
Knight RT
影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
诱发和诱发的振荡活动导致精神分裂症的听觉感觉门控异常
影响因子：
5.7
作者：
Tzvetan Popov;Todor Jordanov;N. Weisz;T. Elbert;B. Rockstroh;G. A. Miller
通讯作者：
G. A. Miller
影响因子：
3.7
作者：
Groppe DM;Urbach TP;Kutas M
通讯作者：
Kutas M
影响因子：
2.9
作者：
Popov，Tzvetan G.;Rockstroh，Brigitte S.;Miller，Gregory A.
通讯作者：
Miller，Gregory A.