Analysis of quantitative magnetic resonance imaging and biomechanical parameters on human discs with different grades of degeneration.
Analysis of quantitative magnetic resonance imaging and biomechanical parameters on human discs with different grades of degeneration.
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DOI：
10.1002/jmri.24120
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发表时间：
2013-12
影响因子：
4.4
通讯作者：
Mwale, Fackson
中科院分区：
文献类型：
--
作者：
Antoniou, John;Epure, Laura F.;Michalek, Arthur J.;Grant, Michael P.;Iatridis, James C.;Mwale, Fackson
To establish relationships between quantitative magnetic resonance imaging (qMRI) and biomechanical parameters to help inform and interpret alterations of human intervertebral discs (IVD) with different grades of degeneration. The properties of the nucleus pulposus (NP) and annulus fibrosus (AF) tissues of each IVD of 10 lumbar spines (range 32–77 years) were analyzed by qMRI (relaxation times T1 and T2, magnetization transfer ratio MTR and apparent diffusion coefficient ADC), and tested in confined compression and dynamic shear. T1 and T2 significantly decreased in both the NP and AF with increasing degeneration grades while the MTR increased significantly with grade 4. In contrast with the others qMRI parameters, the ADC had a tendency to decrease with increasing grade. Disc degeneration caused a decrease in the aggregate modulus, hydraulic permeability and shear modulus magnitude along with an increase in phase angle in the AF. On the other hand, disc degeneration of NPs decreased the shear modulus and the phase angle. Our studies indicate that qMRI can be used as a non-invasive diagnostic tool in the detection of IVDs properties with potential to help interpret and to detect early, middle and late stages of degeneration. QMRI of the human IVD can therefore become a very important diagnostic assessment tool in determining the functional state of the disc.
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影响因子：
3
作者：
MARCHAND, F;AHMED, AM
通讯作者：
AHMED, AM
影响因子：
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作者：
PAAJANEN, H;KOMU, M;HAAPASALO, H
通讯作者：
HAAPASALO, H
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2.8
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Benneker, LM;Heini, PF;Ito, K
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Ito, K
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Kerttula, L;Kurunlahti, M;Tervonen, O
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Tervonen, O
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19.7
作者：
BOOS, N;WALLIN, A;BOESCH, C
通讯作者：
BOESCH, C