Scalable and Recyclable All-Organic Colloidal Cascade Catalysts.
Scalable and Recyclable All-Organic Colloidal Cascade Catalysts.
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DOI：
10.1002/anie.202008104
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发表时间：
2021-01-04
期刊：
影响因子：
--
通讯作者：
Gröschel AH
中科院分区：
文献类型：
--
作者：
Chen C;Janoszka N;Wong CK;Gramse C;Weberskirch R;Gröschel AH
我们报道了通过无表面活性剂乳液聚合（SFEP）合成具有酸催化剂在核中和碱催化剂在壳中的核壳微粒（CSM）。有机催化单体在三个合成步骤中分别共聚，从而允许 CSM 内不相容的酸和碱催化剂的空间分离。重要的是，使用受保护且可热分解的磺酸盐单体作为酸源，以避免壳形成过程中碱催化剂的中和，这是获得稳定的、具有催化活性的CSM的关键。该催化剂在各种溶剂（包括水）中建立的一锅模型级联反应中表现出优异的性能，该反应涉及酸催化脱缩醛化，然后是碱催化 Knoevenagel 缩合。 CSM 易于回收、改性，并且其合成具有可扩展性，使其成为有机催化应用的有希望的候选者。通过两步无表面活性剂乳液聚合合成了全有机核壳胶体催化剂。该酸/碱胶体催化剂在水中表现出较高的催化活性，可以放大和回收，显示出其实际应用的潜力。
We report on the synthesis of core–shell microparticles (CSMs) with an acid catalyst in the core and a base catalyst in the shell by surfactant‐free emulsion polymerization (SFEP). The organocatalytic monomers were separately copolymerized in three synthetic steps allowing the spatial separation of incompatible acid and base catalysts within the CSMs. Importantly, a protected and thermo‐decomposable sulfonate monomer was used as acid source to circumvent the neutralization of the base catalyst during shell formation, which was key to obtain stable, catalytically active CSMs. The catalysts showed excellent performance in an established one‐pot model cascade reaction in various solvents (including water), which involved an acid‐catalyzed deacetalization followed by a base‐catalyzed Knoevenagel condensation. The CSMs are easily recycled, modified, and their synthesis is scalable, making them promising candidates for organocatalytic applications. An all‐organic core–shell colloidal catalyst was synthesized through two‐step surfactant‐free emulsion polymerization. The acid/base colloidal catalyst shows high catalytic activity in water, can be scaled up and recycled, indicating its potential for practical applications.
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