Can depressed cancer patients with a borderline thiamine concentration develop deficiency within a short time period?
Can depressed cancer patients with a borderline thiamine concentration develop deficiency within a short time period?
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硫胺素浓度处于临界值的抑郁癌症患者会在短时间内出现缺乏症吗？
DOI：
10.1017/s1478951522001808
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发表时间：
2023
影响因子：
2.2
通讯作者：
Onishi Hideki
中科院分区：
文献类型：
--
作者：
Uchida Nozomu;Ishida Mayumi;Yoshioka Akira;Sato Izumi;Ito Hiroshi;Onizawa Nobuyuki;Sato Ryota;Mizunuma Naoki;Onishi Hideki
尽管癌症患者中硫胺素缺乏(TD)的报道越来越多，但仍有一些患者的硫胺素浓度(BTC)处于临界值。然而，目前尚不清楚这些患者是否会随后发展为TD。方法在此，我们报告了癌症患者在服用BTC(24-28 ng/ml)后短时间内进展为TD的病例。在治疗抑郁症的过程中，患者表现出食欲下降，血液样本显示BTC(25 ng/ml)。14天后，她报告继续食欲不振，尽管没有韦尼克脑病(WERNICE)的三个典型体征，但进一步的检查显示硫胺素水平为23 ng/ml，导致诊断为TD。Case 2A65岁女性在血管肉瘤化疗期间出现抑郁。她的血样显示BTC(25 ng/ml)。七天后，尽管没有WE的典型体征，但进一步的检测显示硫胺素水平为20毫微克/毫升。Case 3A，41岁的女性在卵巢癌化疗期间患上了抑郁症。没有观察到食欲不振，但血样显示BTC(25 ng/ml)。七天后，尽管没有WE或食欲下降的经典迹象，进一步的测试显示硫胺素水平为19毫微克/毫升。结果的意义BTC抑制的癌症患者可能在短时间内发生TD。为了预防TD，卫生保健专业人员应该保持对其潜力的认识，以及定期检测硫胺素水平或预防性替代疗法的必要性。
BackgroundDespite increasing reports of thiamine deficiency (TD) among cancer patients, there remain some patients with borderline thiamine concentrations (BTC). However, it is unclear whether such patients subsequently develop TD.MethodsHere, we report cases of cancer patients progressing to TD within a short time period after presentation with BTC (24–28 ng/ml).ResultsCase 1A 49-year-old female with lung cancer. During treatment for depression, the patient showed a decreased appetite, and a blood sample revealed BTC (25 ng/ml). Fourteen days later, she reported a continued loss of appetite, and despite the absence of the 3 classical signs of Wernicke encephalopathy (WE), additional testing showed a thiamine level of 23 ng/ml, leading to a diagnosis of TD.Case 2A 65-year-old female developed depression during chemotherapy for angiosarcoma. Her blood sample revealed BTC (25 ng/ml). Seven days later, despite the absence of the classical signs of WE, a further testing revealed a thiamine level of 20 ng/ml.Case 3A 41-year-old female developed depression during chemotherapy for ovarian cancer. No loss of appetite was observed, but a blood sample revealed BTC (25 ng/ml). Seven days later, despite the absence of the classical signs of WE or decreased appetite, further testing revealed a thiamine level of 19 ng/ml.Significance of resultsDepressed cancer patients with BTC may develop TD within a short time frame. To prevent TD, health-care professionals should maintain an awareness of its potential and the need for regular testing of thiamine level or prophylactic replacement therapy.
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602例疑似维生素B1缺乏症患者全血总维生素B1浓度
DOI：
--
发表时间：
2010
期刊：
--
影响因子：
--
作者：
H. Ihara;Takashi Kakinoki;Y. Morita;Y. Shino;K. Takamiya;N. Hashizume
通讯作者：
N. Hashizume
影响因子：
8.4
作者：
AKSOY, M;BASU, TK;DICKERSON, JWT
通讯作者：
DICKERSON, JWT
影响因子：
4.4
作者：
Barbato, Michael;Rodriguez, Paul J.
通讯作者：
Rodriguez, Paul J.
影响因子：
3.3
作者：
BASU, TK;AKSOY, M;DICKERSON, JWT
通讯作者：
DICKERSON, JWT