Pain, affective symptoms, and cognitive deficits in patients with cerebral dopamine dysfunction.
Pain, affective symptoms, and cognitive deficits in patients with cerebral dopamine dysfunction.
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DOI：
10.1016/j.pain.2012.01.002
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发表时间：
2012-04
期刊：
影响因子：
7.4
通讯作者：
London ED
中科院分区：
文献类型：
--
作者：
Jarcho JM;Mayer EA;Jiang ZK;Feier NA;London ED
汇聚临床前，和人类流行病学，神经影像学和遗传学证据表明，多巴胺神经传递在调节疼痛感知和镇痛的核心作用。多巴胺信号传导的失调可以通过增强或减弱伤害性信号的传播直接调节疼痛的体验，也可以通过影响情感和认知过程间接调节疼痛的体验，情感和认知过程影响伤害性信号的预期、体验和解释。对疼痛的超敏反应和慢性疼痛的高共病率在与多巴胺系统功能缺陷相关的疾病中是常见的，包括情绪和情感障碍、物质滥用和帕金森病。然而，对疼痛的低敏感性在精神分裂症患者中很常见，这与过度的多巴胺神经传递有关。虽然患者通常受其疾病的主要症状影响最大，但疼痛感知的改变可能会进一步增加其疾病负担，影响其生活质量。本综述的重点是这种关系，并讨论了临床和潜在的治疗意义与多巴胺相关疾病的患者，和慢性疼痛综合征。
Converging preclinical, and human epidemiological, neuroimaging and genetic evidence suggests a central role for dopamine neurotransmission in modulating pain perception and analgesia. Dysregulation in dopamine signaling may modulate the experience of pain both directly, by enhancing or diminishing the propagation of nociceptive signals, and indirectly, by influencing affective and cognitive processes, which affect the expectation, experience and interpretation of nociceptive signals. Hypersensitivity to pain, and high rates of comorbid chronic pain, are common in disorders linked with deficits in dopamine system function, including disorders of mood and affect, substance abuse, and Parkinson’s disease. Hyposensitivity to pain, however, is common in patients with schizophrenia, which has been linked with excessive dopamine neurotransimssion. Although patients are typically affected most by the primary symptoms of their disorders, alterations in pain perception may further increase the burden of their illness, compromising their quality of life. The present review focuses on this relationship, and discusses clinical and potential therapeutic implications both for patients with dopamine-related disorders, and those with chronic pain syndromes.
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影响因子：
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DOI：
10.1073/pnas.97.14.8104
发表时间：
2000-07-05
影响因子：
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作者：
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