Associations of SARS-CoV-2 serum IgG with occupation and demographics of military personnel.
Associations of SARS-CoV-2 serum IgG with occupation and demographics of military personnel.
复制标题
DOI：
10.1371/journal.pone.0251114
复制
发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Redlich CA
中科院分区：
文献类型：
--
作者：
Zell J;Wisnewski AV;Liu J;Klein J;Lucas C;Slade M;Iwasaki A;Redlich CA
全球各国已动员其武装部队应对 COVID-19，这使得他们面临更大的病毒暴露风险。军事人员对 SARS-CoV-2 的体液反应可作为感染的生物标志物，并为疾病监测和识别工作相关风险因素提供基础。使用酶联免疫吸附测定 (ELISA) 测量 2020 年 4 月至 6 月期间从 N = 988 名美国国民警卫队士兵获得的血清中的 SARS-CoV-2 刺突抗原特异性 IgG。军事操作专业（MOS）代码和人口统计数据通过调查问卷获得。使用活 SARS-CoV-2 进行噬菌斑检测来评估有限受试者 (N = 12) 的血清中和能力。研究人群中 SARS-CoV-2 IgG 血清阳性率为 10.3%，与职业和人口统计数据显着相关。在 MOS 2T 运输行业（3.6；95% CI 0.7–18）和 92F 燃油专家/地面和飞机工作人员（6.8；95% CI 1.5–30）以及黑人种族（2.2；95% CI 1.2–4.1）、家庭规模≥6 人（2.5；95% CI 1.2–4.1）的比值比最高1.3–4.6）和已知的 COVID-19 暴露（2.0；95% CI 1.2–3.3）。血清阳性沿着主要州际公路蔓延，并聚集在国际机场和纽约市边境附近。 SARS-CoV-2 刺突 IgG+ 血清表现出低至中等的 SARS-CoV-2 中和能力，IC50 范围为 1:15 至 1:280。在有限的后续测试中，SARS-CoV-2 血清 IgG 水平在长达 7 个月的时间里一直保持升高状态。这些数据突显了国民警卫队与当地平民中 SARS-CoV-2 血清流行率的增加，这与交通相关职业和特定人口统计数据有关。
Countries across the globe have mobilized their armed forces in response to COVID-19, placing them at increased risk for viral exposure. Humoral responses to SARS-CoV-2 among military personnel serve as biomarkers of infection and provide a basis for disease surveillance and recognition of work-related risk factors. Enzyme-linked immunosorbent assays (ELISA) were used to measure SARS-CoV-2 spike antigen-specific IgG in serum obtained from N = 988 US National Guard soldiers between April-June 2020. Occupational information, e.g. military operating specialty (MOS) codes, and demographic data were obtained via questionnaire. Plaque assays with live SARS-CoV-2 were used to assess serum neutralizing capacity for limited subjects (N = 12). The SARS-CoV-2 IgG seropositivity rate among the study population was 10.3% and significantly associated with occupation and demographics. Odds ratios were highest for those working in MOS 2T-Transportation (3.6; 95% CI 0.7–18) and 92F-Fuel specialist/ground and aircraft (6.8; 95% CI 1.5–30), as well as black race (2.2; 95% CI 1.2–4.1), household size ≥6 (2.5; 95% CI 1.3–4.6) and known COVID-19 exposure (2.0; 95% CI 1.2–3.3). Seropositivity tracked along major interstate highways and clustered near the international airport and the New York City border. SARS-CoV-2 spike IgG+ serum exhibited low to moderate SARS-CoV-2 neutralizing capacity with IC50s ranging from 1:15 to 1:280. In limited follow-up testing SARS-CoV-2 serum IgG levels remained elevated up to 7 months. The data highlight increased SARS-CoV-2 seroprevalence among National Guard vs. the local civilian population in association with transportation-related occupations and specific demographics.
登录
查看更多内容
DOI：
10.1016/j.amjmed.2020.09.024
发表时间：
2021-04
期刊：
The American journal of medicine
影响因子：
--
作者：
Mahajan S;Srinivasan R;Redlich CA;Huston SK;Anastasio KM;Cashman L;Massey DS;Dugan A;Witters D;Marlar J;Li SX;Lin Z;Hodge D;Chattopadhyay M;Adams MD;Lee C;Rao LV;Stewart C;Kuppusamy K;Ko AI;Krumholz HM
通讯作者：
Krumholz HM
影响因子：
3.1
作者：
Kalkman, Jori Pascal
通讯作者：
Kalkman, Jori Pascal
影响因子：
82.9
作者：
Amanat F;Stadlbauer D;Strohmeier S;Nguyen THO;Chromikova V;McMahon M;Jiang K;Arunkumar GA;Jurczyszak D;Polanco J;Bermudez-Gonzalez M;Kleiner G;Aydillo T;Miorin L;Fierer DS;Lugo LA;Kojic EM;Stoever J;Liu STH;Cunningham-Rundles C;Felgner PL;Moran T;García-Sastre A;Caplivski D;Cheng AC;Kedzierska K;Vapalahti O;Hepojoki JM;Simon V;Krammer F
通讯作者：
Krammer F
DOI：
10.3390/v12090949
发表时间：
2020-08-27
期刊：
Viruses
影响因子：
--
作者：
Pirnay JP;Selhorst P;Cochez C;Petrillo M;Claes V;Van der Beken Y;Verbeken G;Degueldre J;T'Sas F;Van den Eede G;Weuts W;Smets C;Mertens J;Geeraerts P;Ariën KK;Neirinckx P;Soentjens P
通讯作者：
Soentjens P
影响因子：
3.7
作者：
Wisnewski AV;Campillo Luna J;Redlich CA
通讯作者：
Redlich CA