Photoacoustic tomography: principles and advances.

Photoacoustic tomography: principles and advances.
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光声断层扫描:原理和进步。

DOI:
10.2528/pier14032303
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发表时间:
2014
期刊:
Electromagnetic waves (Cambridge, Mass.)
影响因子:
--
通讯作者:
Wang LV
Wang LV
中科院分区:
其他
文献类型:
--
作者:
Xia J;Yao J;Wang LV

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光声断层成像(PAT)是一种新兴的成像方式,显示出巨大的潜力,为临床前研究和临床实践。作为一种混合技术,PAT基于对来自内源性发色团(例如氧合血红蛋白和脱氧血红蛋白)或外源性造影剂(例如有机染料和纳米颗粒)的光学吸收的声学检测。由于超声在组织中的散射比光少得多,PAT在光学弹道和扩散机制中生成高分辨率图像。在过去的十年中,光声技术发展迅速,导致了各种令人兴奋的发现和应用。本文介绍了PAT的基本原理及其不同的实现方式。沿着最新成像结果,突出显示PAT的优势。
Photoacoustic tomography (PAT) is an emerging imaging modality that shows great potential for preclinical research and clinical practice. As a hybrid technique, PAT is based on the acoustic detection of optical absorption from either endogenous chromophores, such as oxy-hemoglobin and deoxy-hemoglobin, or exogenous contrast agents, such as organic dyes and nanoparticles. Because ultrasound scatters much less than light in tissue, PAT generates high-resolution images in both the optical ballistic and diffusive regimes. Over the past decade, the photoacoustic technique has been evolving rapidly, leading to a variety of exciting discoveries and applications. This review covers the basic principles of PAT and its different implementations. Strengths of PAT are highlighted, along with the most recent imaging results.
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