Genetic and functional profiling of Crohn's disease: autophagy mechanism and susceptibility to infectious diseases.
Genetic and functional profiling of Crohn's disease: autophagy mechanism and susceptibility to infectious diseases.
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DOI：
10.1155/2013/297501
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发表时间：
2013
影响因子：
--
通讯作者：
Crovella S
中科院分区：
文献类型：
--
作者：
Marcuzzi A;Bianco AM;Girardelli M;Tommasini A;Martelossi S;Monasta L;Crovella S
克罗恩病是一种复杂的疾病，其中基因组、微生物组和环境相互作用以产生疾病的免疫学背景。儿童期疾病更为广泛，其特点是进展迅速，导致疾病过程中的严重影响。几种遗传变异与患该疾病的风险增加有关，其中大多数也与其他自身免疫性疾病有关。肠道有许多层防御管腔微生物的入侵，包括上皮屏障和先天性和适应性免疫反应。此外，最近的证据表明，细菌和病毒感染，以及炎性体基因和自噬过程中涉及的基因，涉及克罗恩病的发病机制。本综述的目的是确定诊断系统可以改善多少，从而提高克罗恩病诊断的成功率。对不久的将来的主要期望是能够预测儿童期疾病的可能后果，从而预防相关并发症，并为每个患者选择最佳治疗方法。
Crohn's disease is a complex disease in which genome, microbiome, and environment interact to produce the immunological background of the disease. Disease in childhood is more extensive and characterized by a rapid progression, leading to severe repercussions in the course of the disorder. Several genetic variations have been associated with an increased risk of developing the disease and most of these are also implicated in other autoimmune disorders. The gut has many tiers of defense against incursion by luminal microbes, including the epithelial barrier and the innate and adaptive immune responses. Moreover, recent evidence shows that bacterial and viral infections, as well as inflammasome genes and genes involved in the autophagy process, are implicated in Crohn's disease pathogenesis. The aim of this review is to establish how much the diagnostic system can improve, thus increasing the success of Crohn's disease diagnosis. The major expectation for the near future is to be able to anticipate the possible consequences of the disease already in childhood, thus preventing associated complications, and to choose the best treatment for each patient.
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