Revisiting the critical weight hypothesis for regulation of pubertal timing in boys.
Revisiting the critical weight hypothesis for regulation of pubertal timing in boys.
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DOI：
10.1093/ajcn/nqaa304
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发表时间：
2021-01-04
期刊：
影响因子：
--
通讯作者：
Ohlsson C
中科院分区：
文献类型：
--
作者：
Bygdell M;Kindblom JM;Jansson JO;Ohlsson C
最近的研究结果表明，在青春期后的啮齿动物和人类的体重有一个体重感应稳态调节。体重感知也可能参与调节青春期的时间。尽管早期的一项小型研究表明，女孩的青春期时间有一个关键的体重，但大多数研究都集中在BMI上，并报告了BMI和青春期时间之间的负相关。在目前的纵向有力队列研究中，我们重新审视了临界体重假说，并检验了青春期前体重是否比青春期前BMI更能有效地预测男孩的青春期时间。我们纳入了哥德堡大型BMI流行病学研究（BEST）（合并BEST队列n = 33,436）中1945-1961年出生的男性（老队列，n = 31,971）和1981-1996年出生的男性（新队列，n = 1465）。研究对象包括具有青春期前体重、8岁时体重指数（BMI）和峰值高度速度（PHV，一种衡量青春期时间的客观指标）信息的男性。在老年队列和近期队列中，体重比BMI更能解释PHV年龄的差异（合并队列，体重6.3%,BMI 3.6%）。体重（β: - 0.24 SD/SD增加体重；95% CI: - 0.25, - 0.23）和BMI （β: - 0.18 SD/SD增加BMI， 95% CI: - 0.19, - 0.17）与PHV年龄呈负相关，但体重的相关性显著高于BMI （P < 0.001）。总之，青春期前体重是男孩青春期时间比青春期前BMI更可靠的反向预测因子。我们认为体重感知构成了调节青春期时间的反馈机制。
Recent findings indicate that there is a body weight–sensing homeostatic regulation of body weight in postpubertal rodents and humans. It is possible that body weight sensing also might be involved in the regulation of pubertal timing. Although an early small study suggested that there is a critical body weight for pubertal timing in girls, most studies have focused on BMI and reported an inverse association between BMI and pubertal timing. In the present longitudinal well-powered cohort study, we revisited the critical weight hypothesis and tested if prepubertal body weight is a more robust inverse predictor of pubertal timing than prepubertal BMI in boys. We included men born during 1945–1961 (old cohort; n = 31,971) and men born during 1981–1996 (recent cohort; n = 1465) in the large BMI Epidemiology Study (BEST) Gothenburg (combined BEST cohort n = 33,436). Men with information on prepubertal body weight and BMI at 8 y of age and age at peak height velocity (PHV; an objective measure of pubertal timing) were included. Body weight explained more of the variance in age at PHV than BMI in both the old cohort and the recent cohort (combined cohort, body weight 6.3%, BMI 3.6%). Both body weight (β: −0.24 SD/SD increase in weight; 95% CI: −0.25, −0.23) and BMI (β: −0.18 SD/SD increase in BMI, 95% CI: −0.19, −0.17) were inversely associated with age at PHV but the association for body weight was significantly more pronounced than the association for BMI (P < 0.001). In conclusion, prepubertal body weight is a more robust inverse predictor of pubertal timing than prepubertal BMI in boys. We propose that body weight sensing constitutes a feedback mechanism to regulate pubertal timing.
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体重体重稳态，可独立于大鼠和小鼠的瘦素来调节脂肪质量。
DOI：
10.1073/pnas.1715687114
发表时间：
2018-01-09
影响因子：
11.1
作者：
Jansson JO;Palsdottir V;Hägg DA;Schéle E;Dickson SL;Anesten F;Bake T;Montelius M;Bellman J;Johansson ME;Cone RD;Drucker DJ;Wu J;Aleksic B;Törnqvist AE;Sjögren K;Gustafsson JÅ;Windahl SH;Ohlsson C
通讯作者：
Ohlsson C
影响因子：
7.7
作者：
Kindblom, Jenny M.;Lorentzon, Mattias;Ohlsson, Claes
通讯作者：
Ohlsson, Claes
影响因子：
5.8
作者：
Crocker, Melissa K.;Stern, Elizabeth A.;Yanovski, Jack A.
通讯作者：
Yanovski, Jack A.
影响因子：
8
作者：
Davison, KK;Susman, EJ;Birch, LL
通讯作者：
Birch, LL
影响因子：
8
作者：
Kaplowitz, PB;Slora, EJ;Herman-Giddens, ME
通讯作者：
Herman-Giddens, ME