Recruitment of parvalbumin and somatostatin interneuron inputs to adult born dentate granule neurons.
Recruitment of parvalbumin and somatostatin interneuron inputs to adult born dentate granule neurons.
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DOI：
10.1038/s41598-020-74385-2
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发表时间：
2020-10-16
影响因子：
4.6
通讯作者：
Contractor A
中科院分区：
文献类型：
--
作者：
Remmers CL;Castillon CCM;Armstrong JN;Contractor A
GABA是成人出生的齿状颗粒细胞（abDGC）成熟的关键调节因子，因此需要绘制abDGC和局部中间神经元之间的功能连接，以了解它们的发育和整合到海马回路中。我们记录了小鼠中出生的abDGC和光活化的小白蛋白（PV）和生长抑素（SST）中间神经元，以绘制分化后前4周期间abDGC输入的时间和强度。abDGC在第一周接受PV中间神经元的输入，但SST输入直到第二周才被检测到。对去极化量子事件的分析表明，abDGC上的GABA能突触数量随着成熟而增加，而单个突触强度是恒定的。在小鼠中自主跑轮通过增加来自两种中间神经元类型的突触接触的数量来缩放GABA能输入到abDGC。这表明对abDGC的GABA能神经支配在延长的有丝分裂后时期和SST和PV突触传入两者的运行尺度期间发展。
GABA is a key regulator of adult-born dentate granule cell (abDGC) maturation so mapping the functional connectivity between abDGCs and local interneurons is required to understand their development and integration into the hippocampal circuit. We recorded from birthdated abDGCs in mice and photoactivated parvalbumin (PV) and somatostatin (SST) interneurons to map the timing and strength of inputs to abDGCs during the first 4 weeks after differentiation. abDGCs received input from PV interneurons in the first week, but SST inputs were not detected until the second week. Analysis of desynchronized quantal events established that the number of GABAergic synapses onto abDGCs increased with maturation, whereas individual synaptic strength was constant. Voluntary wheel running in mice scaled the GABAergic input to abDGCs by increasing the number of synaptic contacts from both interneuron types. This demonstrates that GABAergic innervation to abDGCs develops during a prolonged post-mitotic period and running scales both SST and PV synaptic afferents.
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影响因子：
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作者：
Heigele, Stefanie;Sultan, Sebastien;Bischofberger, Josef
通讯作者：
Bischofberger, Josef
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通讯作者：
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