Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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DOI：
10.3390/vaccines4030023
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发表时间：
2016-06-29
期刊：
影响因子：
7.8
通讯作者：
Fleming SB
中科院分区：
文献类型：
--
作者：
Fleming SB
干扰素（IFN）诱导的抗病毒应答是对抗病毒感染的最早和最有效的先天应答之一。IFN对Janus激酶/信号转导和转录激活（JAK/STAT）信号通路的诱导导致数百个干扰素刺激基因（ISG）的上调，其中许多基因具有快速杀死感染细胞内病毒的能力。在漫长的进化过程中，病毒已经进化出一系列特别的策略来抵消宿主的免疫应答，特别是通过靶向JAK/STAT信号通路。了解干扰素系统是如何被抑制提供了关键的见解病毒的毒力和发病机制。此外，对病毒编码的调节JAK/STAT途径的因子的鉴定为通过反向遗传学创造新的抗病毒药物和合理减毒的新一代疫苗（特别是针对RNA病毒的疫苗）开辟了机会。
The interferon (IFN) induced anti-viral response is amongst the earliest and most potent of the innate responses to fight viral infection. The induction of the Janus kinase/signal transducer and activation of transcription (JAK/STAT) signalling pathway by IFNs leads to the upregulation of hundreds of interferon stimulated genes (ISGs) for which, many have the ability to rapidly kill viruses within infected cells. During the long course of evolution, viruses have evolved an extraordinary range of strategies to counteract the host immune responses in particular by targeting the JAK/STAT signalling pathway. Understanding how the IFN system is inhibited has provided critical insights into viral virulence and pathogenesis. Moreover, identification of factors encoded by viruses that modulate the JAK/STAT pathway has opened up opportunities to create new anti-viral drugs and rationally attenuated new generation vaccines, particularly for RNA viruses, by reverse genetics.
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影响因子：
3.8
作者：
Bartlett, NW;Buttigieg, K;Smith, GL
通讯作者：
Smith, GL
影响因子：
5.4
作者：
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通讯作者：
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DOI：
10.1073/pnas.0504666102
发表时间：
2005-09-06
影响因子：
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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