Mechanism for food texture preference based on grittiness.
Mechanism for food texture preference based on grittiness.
复制标题
基于砂砾度的食物质地偏好机制。
DOI：
10.1016/j.cub.2021.02.007
复制
发表时间：
2021-05-10
期刊：
影响因子：
--
通讯作者：
Montell C
中科院分区：
文献类型：
--
作者：
Li Q;Montell C
动物接受或拒绝预期食物的决定只是部分基于其化学成分。适口性也受到质地特征的极大影响，包括光滑度与砂砾度，砂砾度受颗粒大小的影响。在这里，我们证明了果蝇被赋予了辨别食物中颗粒大小的能力，并利用这些信息来决定食物是否有吸引力。这一决定取决于一个机械激活的通道，OSCA/TMEM 63，这是保守的从植物到人类。我们发现，tmem 63表达在一个多树突状神经元（md-L）在苍蝇的舌头。tmem 63的缺失会削弱机械刺激对md-L的激活以及根据颗粒大小选择食物的能力。这些发现揭示了这种进化上保守的、机械激活的TMEM 63通道在动物中的第一个作用，并解释了苍蝇如何感知和行为上对颗粒提供的食物质地做出反应。在人类中，食物中颗粒的大小影响适口性。Li和Montell证实，苍蝇也会评估食物中颗粒的大小，并利用这些信息来评估食物的吸引力。苍蝇通过机械激活舌头中多树突神经元（md-L）中的TMEM 63通道来区分食物中的颗粒大小。
An animal’s decision to accept or reject a prospective food is based only in part on its chemical composition. Palatability is also greatly influenced by textural features including smoothness versus grittiness, which is influenced by particle sizes. Here, we demonstrate that Drosophila melanogaster is endowed with the ability to discriminate particle sizes in food and uses this information to decide whether a food is appealing. The decision depends on a mechanically-activated channel, OSCA/TMEM63, which is conserved from plants to humans. We found that tmem63 is expressed in a multidendritic neuron (md-L) in the fly tongue. Loss of tmem63 impairs the activation of md-L by mechanical stimuli and the ability to choose food based on particle size. These findings reveal the first role for this evolutionarily conserved, mechanically-activated TMEM63 channel in an animal and provide an explanation as to how flies can sense and behaviorally respond to the texture of food provided by particles. In humans the size of particles in food influences palatability. Li and Montell establish that flies also evaluate the size of particles in food and use this information to assess its appeal. Flies discriminate particle sizes in food through mechanical activation of the TMEM63 channel in a multidendritic neuron (md-L) in their tongue.
登录
查看更多内容
DOI：
10.3791/193
发表时间：
2007-01-01
期刊：
Journal of visualized experiments : JoVE
影响因子：
--
作者：
Shiraiwa, Takashi;Carlson, John R
通讯作者：
Carlson, John R
DUF221 蛋白是真核生物中保守的渗透敏感钙渗透性阳离子通道家族
影响因子：
44.1
作者：
通讯作者：
--
假定的毛细胞机械转导通道 TMC1 和 TMEM16 蛋白之间的结构关系。
影响因子：
7.7
作者：
Ballesteros A;Fenollar-Ferrer C;Swartz KJ
通讯作者：
Swartz KJ
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
16.2
作者：
Pan B;Akyuz N;Liu XP;Asai Y;Nist-Lund C;Kurima K;Derfler BH;György B;Limapichat W;Walujkar S;Wimalasena LN;Sotomayor M;Corey DP;Holt JR
通讯作者：
Holt JR