Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine as a heterologous booster.
Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine as a heterologous booster.
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DOI：
10.1016/j.isci.2022.105465
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发表时间：
2022-11-18
期刊：
影响因子：
5.8
通讯作者：
Huang, Ailong
中科院分区：
文献类型：
--
作者：
Peng, Pai;Feng, Chengqian;Hu, Jie;He, Changlong;Deng, Haijun;Fan, Qinghong;Xiang, Jin;Tang, Guofang;Jiang, Meng-ling;Hu, Fengyu;Li, Feng;Wang, Kai;Tang, Ni;Tang, Xiao-ping;Huang, Ailong
为了克服由Omicron变异引起的SARS-CoV-2再感染或疫苗接种后感染的风险增加，Omicron特异性疫苗被认为是一种潜在的策略。我们报道了与未接种WT感染相比，接种后δ和Omicron感染引起的针对VOCs的抗体反应的幅度和广度增加。然后，在小鼠模型中，三剂量的Omicron-RBD免疫与三剂量的WT-RBD免疫产生相当的中和抗体（NAb）滴度，但中和活性不交叉活性。相比之下，在两剂WT-RBD免疫后，异源的Omicron- rbd增强剂比同源的WT-RBD增强剂提高了针对Omicron的NAb滴度9倍。此外，它保留了对WT和当前VOCs的中和作用。结果表明，omicon特异性亚单位增强剂在WT和当前VOCs的免疫保护中都具有优势，并且包含两种或两种以上病毒谱系的SARS-CoV-2疫苗可能会改善NAb应答。接种后感染SARS-CoV-2可引起更高和更广泛的免疫应答。含有Omicron- rbd蛋白的异源增强剂可使NAb增加9倍
To overcome the increased risk of SARS-CoV-2 reinfection or post-vaccination infection caused by the Omicron variant, Omicron-specific vaccines were considered a potential strategy. We reported the increased magnitude and breadth of antibody response against VOCs elicited by post-vaccination Delta and Omicron infection, compared to WT infection without vaccination. Then, in mouse models, three doses of Omicron-RBD immunization elicited comparable neutralizing antibody (NAb) titers with three doses of WT-RBD immunization, but the neutralizing activity was not cross-active. By contrast, a heterologous Omicron-RBD booster following two doses of WT-RBD immunization increased the NAb titers against Omicron by 9-folds than the homologous WT-RBD booster. Moreover, it retains neutralization against both WT and current VOCs. Results suggest that Omicron-specific subunit booster shows its advantages in the immune protection from both WT and current VOCs and that SARS-CoV-2 vaccines including two or more virus lineages might improve the NAb response. Post-vaccination SARS-CoV-2 infection can elicit higher and boarder immune response A heterologous booster with the Omicron-RBD protein elicits a 9-fold increased NAb Heterologous boosting with Omicron enhance the potency and breadth of immune response Virology
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DOI：
10.1056/nejmoa2119451
发表时间：
2022-04-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Andrews N;Stowe J;Kirsebom F;Toffa S;Rickeard T;Gallagher E;Gower C;Kall M;Groves N;O'Connell AM;Simons D;Blomquist PB;Zaidi A;Nash S;Iwani Binti Abdul Aziz N;Thelwall S;Dabrera G;Myers R;Amirthalingam G;Gharbia S;Barrett JC;Elson R;Ladhani SN;Ferguson N;Zambon M;Campbell CNJ;Brown K;Hopkins S;Chand M;Ramsay M;Lopez Bernal J
通讯作者：
Lopez Bernal J
DOI：
10.1016/j.medj.2022.02.006
发表时间：
2022-04-08
期刊：
Med (New York, N.Y.)
影响因子：
--
作者：
Miyamoto S;Arashiro T;Adachi Y;Moriyama S;Kinoshita H;Kanno T;Saito S;Katano H;Iida S;Ainai A;Kotaki R;Yamada S;Kuroda Y;Yamamoto T;Ishijima K;Park ES;Inoue Y;Kaku Y;Tobiume M;Iwata-Yoshikawa N;Shiwa-Sudo N;Tokunaga K;Ozono S;Hemmi T;Ueno A;Kishida N;Watanabe S;Nojima K;Seki Y;Mizukami T;Hasegawa H;Ebihara H;Maeda K;Fukushi S;Takahashi Y;Suzuki T
通讯作者：
Suzuki T
影响因子：
64.5
作者：
Cui Z;Liu P;Wang N;Wang L;Fan K;Zhu Q;Wang K;Chen R;Feng R;Jia Z;Yang M;Xu G;Zhu B;Fu W;Chu T;Feng L;Wang Y;Pei X;Yang P;Xie XS;Cao L;Cao Y;Wang X
通讯作者：
Wang X
影响因子：
39.3
作者：
Wang J
通讯作者：
Wang J
DOI：
10.1126/science.abn4947
发表时间：
2022-05-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Pulliam JRC;van Schalkwyk C;Govender N;von Gottberg A;Cohen C;Groome MJ;Dushoff J;Mlisana K;Moultrie H
通讯作者：
Moultrie H