The neostriatum: two entities, one structure?
The neostriatum: two entities, one structure?
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新纹状体：两个实体，一个结构？
DOI：
--
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发表时间：
2015
影响因子：
3.1
通讯作者：
G. Arbuthnott
中科院分区：
文献类型：
--
作者：
Violeta G. Lopez;Y. Nakano;Johannes Bausenwein;Omar Jáidar;M. Lazarus;Yoan Cherassse;M. Garcia;G. Arbuthnott
纹状体（或补丁）首先被确定与解剖技术作为神经元组织在一个三维的迷宫插入和交错的其余部分新纹状体：矩阵。纹状体和基质迅速成为两个神经元隔室表达不同的生化标志物，胚胎发育和传入和传出连接。尽管广泛的内在神经元轴突和树突的延伸应该交换信息之间的矩阵和纹状体，证据表明存在独立的领域。在这里，我们报告说，这两个区域确实不交换突触信息。我们使用的基因表达通道视紫红质2携带的腺相关病毒血清型10（AAVrh 10），只表达在神经元的基质室。全细胞膜片钳记录的基质神经元激活的光脉冲一致产生抑制性突触后电流（IPSC），但同样的操作没有引起IPSC在纹状体神经元。该基质包含直接和间接纹状体输出通路。通过靶向由AAVrh 10携带的设计者药物（DREADD）hM 3di专门激活的设计者受体的纹状体基质表达，我们能够在学习的单颗粒伸手抓握任务的执行期间抑制背外侧纹状体的基质神经元隔室。正如预期的那样，通过全身给予DREADD激动剂氯氮平-N-氧化物抑制基质神经元干扰了学习任务的表现。
The striosome (or patch) was first identified with anatomical techniques as neurons organized in a three-dimensional labyrinth inserted in and interdigitating the rest of neostriatum: the matrix. Striosome and matrix rapidly became known as two neuronal compartments expressing different biochemical markers, embryonic development and afferent and efferent connectivity. In spite of extensive intrinsic neuronal axonal and dendritic extensions supposed to exchange information between matrix and striosomes, evidence suggested the presence of independent areas. Here, we report that indeed these two areas do not exchange synaptic information. We used genetic expression of channel rhodopsin 2 carried by adeno-associated virus serotype 10 (AAVrh10) that only expresses in neurons of the matrix compartment. Whole-cell patch-clamp recordings of matrix neurons activated by light pulses consistently produced inhibitory postsynaptic currents (IPSCs), but the same manipulation did not evoke IPSCs in striosome neurons. The matrix contains both direct and indirect striatal output pathways. By targeting striatal matrix expression of designer receptors exclusively activated by a designer drug (DREADD) hM3di carried by AAVrh10, we were able to inhibit the matrix neuronal compartment of the dorsolateral striatum during performance of a learned single-pellet reach-to-grasp task. As expected, inhibition of matrix neurons by systemic administration of DREADD agonist clozapine-n-oxide interfered with performance of the learned task.
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影响因子：
12.4
作者：
Cearley, CN;Wolfe, JH
通讯作者：
Wolfe, JH
DOI：
10.1038/mt.2008.166
发表时间：
2008-10
期刊：
Molecular therapy : the journal of the American Society of Gene Therapy
影响因子：
--
作者：
通讯作者：
--
灵长类纹状体基质区室中投射神经元的模块化组织。
DOI：
10.1523/jneurosci.11-03-00779.1991
发表时间：
1991
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Gimenez-Amaya,JM;Graybiel,AM
通讯作者：
Graybiel,AM
影响因子：
2.1
作者：
Aldridge, JW;Berridge, KC;Rosen, AR
通讯作者：
Rosen, AR
影响因子：
2.5
作者：
KAWAGUCHI, Y;WILSON, CJ;EMSON, PC
通讯作者：
EMSON, PC