Intermittent hypoxia training: Powerful, non-invasive cerebroprotection against ethanol withdrawal excitotoxicity.
Intermittent hypoxia training: Powerful, non-invasive cerebroprotection against ethanol withdrawal excitotoxicity.
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DOI：
10.1016/j.resp.2017.08.007
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发表时间：
2018-10
影响因子：
2.3
通讯作者：
Mallet RT
中科院分区：
文献类型：
--
作者：
Jung ME;Mallet RT
酒精中毒和戒断会对中枢神经系统造成毁灭性的损害。突然的乙醇戒断引起兴奋性神经递质谷氨酸的大量释放，其过度激活其突触后受体，引起强烈的Ca2+负载、p38有丝分裂原激活的蛋白激酶激活和氧化应激，最终导致ATP耗竭、线粒体损伤、淀粉样蛋白β沉积和神经元死亡。总的来说，这些机制产生神经认知和感觉运动功能障碍，阻碍继续禁欲。虽然大脑严重依赖血液中的O2来维持其有氧ATP的产生，但当在数天或数周内明智地应用短暂的中度缺氧和复氧循环时，会引起适应性变化，保护大脑免受乙醇戒断诱导的谷氨酸兴奋性毒性、线粒体损伤、氧化应激和淀粉样蛋白β积累的影响。本文综述了正在进行的临床前研究的证据，这些研究表明间歇性低氧训练是一种潜在的强大而非侵入性的干预措施，能够在乙醇戒断期间提供强大，持续的神经保护。
Ethanol intoxication and withdrawal exact a devastating toll on the central nervous system. Abrupt ethanol withdrawal provokes massive release of the excitatory neurotransmitter glutamate, which over-activates its postsynaptic receptors, causing intense Ca2+ loading, p38 mitogen activated protein kinase activation and oxidative stress, culminating in ATP depletion, mitochondrial injury, amyloid β deposition and neuronal death. Collectively, these mechanisms produce neurocognitive and sensorimotor dysfunction that discourages continued abstinence. Although the brain is heavily dependent on blood-borne O2 to sustain its aerobic ATP production, brief, cyclic episodes of moderate hypoxia and reoxygenation, when judiciously applied over the course of days or weeks, evoke adaptations that protect the brain from ethanol withdrawal-induced glutamate excitotoxicity, mitochondrial damage, oxidative stress and amyloid β accumulation. This review summarizes evidence from ongoing preclinical research that demonstrates intermittent hypoxia training to be a potentially powerful yet non-invasive intervention capable of affording robust, sustained neuroprotection during ethanol withdrawal.
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影响因子：
4.2
作者：
Jung ME;Ju X;Metzger DB;Simpkins JW
通讯作者：
Simpkins JW
影响因子：
4.6
作者：
Bu XL;Liu YH;Wang QH;Jiao SS;Zeng F;Yao XQ;Gao D;Chen JC;Wang YJ
通讯作者：
Wang YJ
DOI：
10.1002/neu.480230915
发表时间：
1992-11-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
CHOI, DW
通讯作者：
CHOI, DW
DOI：
10.1111/j.1530-0277.2006.00041.x
发表时间：
2006-02-01
影响因子：
3.2
作者：
Chandler, LJ;Carpenter-Hyland, E;Szumlinski, KK
通讯作者：
Szumlinski, KK
影响因子：
7.6
作者：
Abulseoud, Osama A.;Camsari, Ulas M.;Choi, Doo-Sup
通讯作者：
Choi, Doo-Sup