Synaptic Vesicle Endocytosis in Different Model Systems.
Synaptic Vesicle Endocytosis in Different Model Systems.
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DOI：
10.3389/fncel.2018.00171
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发表时间：
2018
影响因子：
5.3
通讯作者：
Watanabe S
中科院分区：
文献类型：
--
作者：
Gan Q;Watanabe S
复杂动物的神经传递依赖于功能不同的突触以高度协调的方式释放神经递质。在突触信号传递过程中，囊泡与质膜融合释放其内容物。囊泡融合的速率很高，可以超过突触囊泡由远处来源重新提供的速率。因此，需要局部代偿性内吞来补充突触囊泡池。在过去的四十年中，各种实验方法和模型系统被用于研究突触囊泡周期的细胞和分子机制。网格蛋白介导的胞吞作用被认为是突触囊泡循环的主要机制。然而，最近的研究表明，其他模式的内吞作用也有重要贡献，包括快速代偿性内吞作用、活性依赖的大量内吞作用、超快速内吞作用以及吻后逃跑。目前，还不清楚是否存在一个适用于所有类型突触的囊泡循环的通用模型。每种突触类型都可能采用特定的内吞作用模式。或者，在同一突触上有多种模式的内吞作用，并且突触根据其活动水平在不同模式之间切换。在此，我们收集了基于特征良好的模型系统的综述和研究文章：青蛙神经肌肉连接，秀丽隐杆线虫神经肌肉连接，果蝇神经肌肉连接，七鳃鳗网状脊髓巨轴突，金鱼视网膜带状突触，Held花萼和啮齿动物海马突触。我们将比较这些系统的已知模式和突触囊泡内吞动力学，以及潜在的分子机制。我们还将提供该领域的未来发展。
Neurotransmission in complex animals depends on a choir of functionally distinct synapses releasing neurotransmitters in a highly coordinated manner. During synaptic signaling, vesicles fuse with the plasma membrane to release their contents. The rate of vesicle fusion is high and can exceed the rate at which synaptic vesicles can be re-supplied by distant sources. Thus, local compensatory endocytosis is needed to replenish the synaptic vesicle pools. Over the last four decades, various experimental methods and model systems have been used to study the cellular and molecular mechanisms underlying synaptic vesicle cycle. Clathrin-mediated endocytosis is thought to be the predominant mechanism for synaptic vesicle recycling. However, recent studies suggest significant contribution from other modes of endocytosis, including fast compensatory endocytosis, activity-dependent bulk endocytosis, ultrafast endocytosis, as well as kiss-and-run. Currently, it is not clear whether a universal model of vesicle recycling exist for all types of synapses. It is possible that each synapse type employs a particular mode of endocytosis. Alternatively, multiple modes of endocytosis operate at the same synapse, and the synapse toggles between different modes depending on its activity level. Here we compile review and research articles based on well-characterized model systems: frog neuromuscular junctions, C. elegans neuromuscular junctions, Drosophila neuromuscular junctions, lamprey reticulospinal giant axons, goldfish retinal ribbon synapses, the calyx of Held, and rodent hippocampal synapses. We will compare these systems in terms of their known modes and kinetics of synaptic vesicle endocytosis, as well as the underlying molecular machineries. We will also provide the future development of this field.
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DOI：
10.1083/jcb.57.2.499
发表时间：
1973-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ceccarelli B;Hurlbut WP;Mauro A
通讯作者：
Mauro A
影响因子：
16.6
作者：
Chiang, Hsueh-Cheng;Shin, Wonchul;Zhao, Wei-Dong;Hamid, Edaeni;Sheng, Jiansong;Baydyuk, Maryna;Wen, Peter J.;Jin, Albert;Momboisse, Fanny;Wu, Ling-Gang
通讯作者：
Wu, Ling-Gang
影响因子：
5.5
作者：
BETZ, WJ;BEWICK, GS
通讯作者：
BEWICK, GS
影响因子：
56.9
作者：
BETZ, WJ;BEWICK, GS
通讯作者：
BEWICK, GS
DOI：
10.1073/pnas.0707574105
发表时间：
2007-12-18
影响因子：
11.1
作者：
Balaji, J.;Ryan, T. A.
通讯作者：
Ryan, T. A.