Hepatitis B Vaccines.

Hepatitis B Vaccines.
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DOI:
10.1093/infdis/jiaa668
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发表时间:
2021-09-30
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Van Damme P
Van Damme P
中科院分区:
其他
文献类型:
--
作者:
Pattyn J;Hendrickx G;Vorsters A;Van Damme P

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B型肝炎是由B型肝炎病毒(HBV)引起的,其感染肝脏并可导致慢性肝病,包括肝硬化和肝细胞癌。HBV代表了一个全球性的公共卫生问题,导致严重的发病率和死亡率。负担得起,安全,有效,B型肝炎疫苗是我们控制和预防B型肝炎的最佳工具。2019年,全球3剂B肝炎疫苗的覆盖率达到85%,而2000年约为30%。B型肝炎疫苗接种计划的有效实施使HBV携带率和乙型肝炎相关发病率和死亡率大幅下降。这篇文章总结了B型肝炎疫苗的巨大成功,这是第一个基于病毒样颗粒的抗癌疫苗。此外,讨论了全球预防HBV感染所需的B型肝炎疫苗接种的现有未解决问题和未来前景。
Hepatitis B is caused by the hepatitis B virus (HBV), which infects the liver and may lead to chronic liver disease, including cirrhosis and hepatocellular carcinoma. HBV represents a worldwide public health problem, causing major morbidity and mortality. Affordable, safe, and effective, hepatitis B vaccines are the best tools we have to control and prevent hepatitis B. In 2019, coverage of 3 doses of the hepatitis B vaccine reached 85% worldwide compared to around 30% in 2000. The effective implementation of hepatitis B vaccination programs has resulted in a substantial decrease in the HBV carrier rate and hepatitis B-related morbidity and mortality. This article summarizes the great triumphs of the hepatitis B vaccine, the first anticancer and virus-like-particle–based vaccine. In addition, existing unresolved issues and future perspectives on hepatitis B vaccination required for global prevention of HBV infection are discussed.
DOI: 10.1001/jama.256.7.869
发表时间: 1986-08-15
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