The burden of chronic spontaneous urticaria is substantial: Real-world evidence from ASSURE-CSU.
The burden of chronic spontaneous urticaria is substantial: Real-world evidence from ASSURE-CSU.
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作者：
Maurer M;Abuzakouk M;Bérard F;Canonica W;Oude Elberink H;Giménez-Arnau A;Grattan C;Hollis K;Knulst A;Lacour JP;Lynde C;Marsland A;McBride D;Nakonechna A;Ortiz de Frutos J;Proctor C;Sussman G;Sweeney C;Tian H;Weller K;Wolin D;Balp MM
慢性自发性荨麻疹（CSU）可以使人衰弱，难以治疗，并令患者和医生感到沮丧。真实的世界证据对CSU的负担是有限的。本研究的目的是记录疾病持续时间、治疗史和疾病活动，以及对控制不佳的CSU患者的健康相关生活质量（HRQoL）和工作的影响，并描述其人文、社会和经济负担。这项国际观察性研究评估了673例接受治疗后症状持续≥12个月的CSU成人患者队列。从病历中收集过去12个月的人口统计学、疾病特征和医疗资源使用情况。从调查和日记中收集患者报告的荨麻疹和血管性水肿症状、HRQoL以及工作效率和活动障碍数据。根据荨麻疹活动性评分报告，近50%的患者具有中度至重度疾病活动性。平均（SD）皮肤病生活质量指数和慢性荨麻疹生活质量问卷评分分别为9.1（6.62）和33.6（20.99）。慢性自发性荨麻疹明显干扰睡眠和日常活动。66%的入组患者报告了过去12个月内的血管性水肿，并显著影响了HRQoL。超过20%的患者报告每周缺勤≥1小时;生产力受损为27%。这些影响随着疾病活动的增加而增加。治疗CSU产生了大量医疗资源和成本。慢性自发性荨麻疹具有相当大的人文和经济影响。疾病活动性和血管性水肿患者的HRQoL受损程度更高。
Chronic spontaneous urticaria (CSU) can be debilitating, difficult to treat, and frustrating for patients and physicians. Real‐world evidence for the burden of CSU is limited. The objective of this study was to document disease duration, treatment history, and disease activity, as well as impact on health‐related quality of life (HRQoL) and work among patients with inadequately controlled CSU, and to describe its humanistic, societal, and economic burden. This international observational study assessed a cohort of 673 adult patients with CSU whose symptoms persisted for ≥12 months despite treatment. Demographics, disease characteristics, and healthcare resource use in the previous 12 months were collected from medical records. Patient‐reported data on urticaria and angioedema symptoms, HRQoL, and work productivity and activity impairment were collected from a survey and a diary. Almost 50% of patients had moderate‐to‐severe disease activity as reported by Urticaria Activity Score. Mean (SD) Dermatology Life Quality Index and Chronic Urticaria Quality of Life Questionnaire scores were 9.1 (6.62) and 33.6 (20.99), respectively. Chronic spontaneous urticaria markedly interfered with sleep and daily activities. Angioedema in the previous 12 months was reported by 66% of enrolled patients and significantly affected HRQoL. More than 20% of patients reported ≥1 hour per week of missed work; productivity impairment was 27%. These effects increased with increasing disease activity. Significant healthcare resources and costs were incurred to treat CSU. Chronic spontaneous urticaria has considerable humanistic and economic impacts. Patients with greater disease activity and with angioedema experience greater HRQoL impairments.
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影响因子：
3.6
作者：
Maurer, Marcus;Magerl, Markus;Zuberbier, Torsten
通讯作者：
Zuberbier, Torsten
影响因子：
12.4
作者：
Baiardini, I;Pasquali, M;Canonica, GW
通讯作者：
Canonica, GW
影响因子：
12.4
作者：
Mlynek, A.;Magerl, M.;Maurer, M.
通讯作者：
Maurer, M.
DOI：
10.1007/s40271-015-0145-9
发表时间：
2015-12
期刊：
The patient
影响因子：
--
作者：
Balp MM;Vietri J;Tian H;Isherwood G
通讯作者：
Isherwood G
影响因子：
3.6
作者：
Flood, Emuella M.;Zazzali, James L.;Devlen, Jennifer
通讯作者：
Devlen, Jennifer