Altered concentrations of appetite regulators may contribute to the development and maintenance of HIV‐associated wasting
Altered concentrations of appetite regulators may contribute to the development and maintenance of HIV‐associated wasting
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食欲调节剂浓度的改变可能有助于艾滋病毒相关消瘦的发生和维持
DOI：
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
J. Vázquez
中科院分区：
文献类型：
--
作者：
F. Arnalich;P. Martínez;Á. Hernanz;Juan R. González;María A. Plaza;C. Montiel;J. Peña;J. Vázquez
目的：探讨循环食欲神经肽CCK-8硫酸盐（CCK-8 s）、β-内啡肽（β-EP）、肿瘤坏死因子-α（TNF-α）和可溶性TNF受体（sTNFR）与HIV感染相关性厌食和消瘦的关系。设计：横断面分析。设置：一所大学为基础的艾滋病毒/艾滋病门诊在马德里，西班牙。对象：36例无合并症或继发感染的艾滋病患者随机分为消瘦组19例，正常体重组17例，健康对照组18例。测量：营养状况通过人体测量、实验室参数和食欲自我报告进行评估。采用酶免疫法测定血浆TNF-α、sTNFR-p55和sTNFR-p75水平，放射免疫法测定CCK-8 s和β-内啡肽水平。结果：AIDS消瘦组血浆CCK-8 s水平显著高于营养良好组（P < 0.01），β-内啡肽水平显著低于对照组（P < 0.001）。AIDS消瘦患者TNF-α、sTNFR-p55和sTNFR-p75的平均水平高于无症状AIDS患者或对照组。在这些循环肽和营养不良的参数之间没有观察到显著的关联。结论：TNF系统的激活，以及两种具有相反食欲调节作用的神经肽血浆浓度的相互变化，即CCK-8 s浓度升高而β-内啡肽水平降低，与HIV消瘦的存在相关。我们假设这些变化可能通过产生食欲的病理性抑制而导致HIV消瘦的发展。
Objective:To examine the relation of circulating appetite neuropeptides, CCK-8 sulphate (CCK-8s) and β-endorphin, and the tumour necrosis factor-alpha (TNF-α) and soluble TNF receptors (sTNFR) to the anorexia and wasting associated with HIV-infection. Design:Cross-sectional analysis. Setting:A university-based HIV/AIDS ambulatory clinic in Madrid, Spain. Participants:Thirty-six randomly selected AIDS patients without concomitant diseases or secondary infections were classified into two groups: 19 patients with wasting and 17 with normal body weight, and 18 healthy controls. Measurements:Nutritional status was evaluated by anthropometry, laboratory parameters and self-report of appetite. Plasma levels of TNF-α and sTNFR proteins p55 (sTNFR-p55) and p75 (sTNFR-p75) were determined by enzyme immunoassay, whereas CCK-8s and β-endorphin levels were measured by radioimmunoassay. Results:AIDS patients with wasting had significantly higher plasma concentrations of CCK-8s, but lower levels of β-endorphin when compared to well-nourished AIDS patients (P < 0.01) or controls (P < 0.001). Mean levels of TNF-α, and sTNFR-p55 and sTNFR-p75 were greater in AIDS patients with wasting than in asymptomatic AIDS patients or in controls. No significant association was observed between any of these circulating peptides and the parameters of malnutrition. Conclusions:An activation of the TNF system, together with reciprocal changes in plasma concentrations of two neuropeptides with opposing appetite regulation, that is increased concentrations of CCK-8s but lower levels of β-endorphin, are associated with the presence of HIV wasting. We hypothesize that these changes may contribute to the development of HIV wasting by producing a pathological inhibition of appetite.
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DOI：
10.1073/pnas.89.11.4845
发表时间：
1992-06-01
影响因子：
11.1
作者：
VANZEE, KJ;KOHNO, T;LOWRY, SF
通讯作者：
LOWRY, SF
神经性厌食症的体内总水量和总钾量。
DOI：
10.1093/ajcn/40.2.260
发表时间：
1984
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Dempsey,DT;Crosby,LO;Lusk,E;Oberlander,JL;Pertschuk,MJ;Mullen,JL
通讯作者：
Mullen,JL
影响因子：
7.1
作者：
KOTLER, DP;TIERNEY, AR;PIERSON, RN
通讯作者：
PIERSON, RN
艾滋病患者的蛋白质和能量底物代谢。
DOI：
10.1016/0026-0495(90)90136-z
发表时间：
1990
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
Stein,TP;Nutinsky,C;Condoluci,D;Schluter,MD;Leskiw,MJ
通讯作者：
Leskiw,MJ