Preliminary evidence for changes in frontoparietal network connectivity in the early abstinence period in alcohol use disorder: a longitudinal resting-state functional magnetic resonance imaging study.
Preliminary evidence for changes in frontoparietal network connectivity in the early abstinence period in alcohol use disorder: a longitudinal resting-state functional magnetic resonance imaging study.
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酒精使用障碍戒断早期额顶顶神经网络连通性改变的初步证据：一项纵向静息状态功能磁共振成像研究。
DOI：
10.3389/fpsyt.2023.1185770
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发表时间：
2023
影响因子：
4.7
通讯作者：
Momenan, Reza
中科院分区：
文献类型：
--
作者：
van Oort, Jasper;Diazgranados, Nancy;George, David T.;Horneffer, Yvonne;Schwandt, Melanie;Goldman, David;Momenan, Reza
早期戒酒期是酒精使用障碍（AUD）的一个关键阶段，在此期间患者必须找到新的平衡，可能开始康复，或者相反，复发。然而，在这一关键时期大脑功能的变化在很大程度上仍然未知。我们着手利用静息态扫描研究早期戒酒期大规模脑网络的纵向变化。我们在一个控制良好的住院环境中对AUD患者进行了两次扫描，第一次扫描在入院后不久进行，第二次扫描在4周（±9天）后治疗期接近结束时进行。我们研究了37名AUD患者（22名男性）和27名健康对照者（16名男性）。我们专注于在AUD中受影响且构成该疾病核心症状维度基础的三个网络：额顶叶网络（左右FPN）和默认模式网络（DMN）。使用双重回归研究了这些网络的全脑以及网络内连接性。最后，我们探究了这些脑网络与各种神经心理学和行为指标之间的相关性。与对照组（Z = -1.081，p = 0.280）相比，AUD患者左侧FPN网络内连接性下降（Z = -2.029，p = 0.042）。然而，这些结果在严格的邦费罗尼校正后并不显著。AUD患者在早期戒酒期左侧FPN连接性下降可能反映出最初FPN上调，在随后的戒酒几周内恢复到较低的静息态连接水平。AUD患者左侧FPN连接性变化与特质焦虑之间呈现正相关趋势（rs = 0.303，p = 0.068），左侧FPN连接性变化与延迟折扣之间呈现负相关趋势（rs = -0.283，p = 0.089）（未进行多重比较校正）。这表明FPN可能参与对冲动和焦虑的自上而下的控制，而冲动和焦虑是复发的重要危险因素。尽管（在多重比较校正后）没有统计学上显著的结果，但我们的初步发现鼓励对临床关键的早期戒酒期的动态神经适应进行进一步研究，并可为未来的研究设计提供参考。
The early abstinence period is a crucial phase in alcohol use disorder (AUD) in which patients have to find a new equilibrium and may start recovery, or conversely, relapse. However, the changes in brain functions during this key period are still largely unknown. We set out to study longitudinal changes in large-scale brain networks during the early abstinence period using resting-state scans. We scanned AUD patients twice in a well-controlled inpatient setting, with the first scan taking place shortly after admission and the second scan 4 weeks (±9 days) later near the end of the treatment period. We studied 37 AUD patients (22 males) and 27 healthy controls (16 males). We focused on three networks that are affected in AUD and underly core symptom dimensions in this disorder: the frontoparietal networks (left and right FPN) and default mode network (DMN). Both the whole brain and within network connectivity of these networks were studied using dual regression. Finally, we explored correlations between these brain networks and various neuropsychological and behavioral measures. In contrast to the controls (Z = −1.081, p = 0.280), the AUD patients showed a decrease in within left FPN connectivity (Z = −2.029, p = 0.042). However, these results did not survive a strict Bonferroni correction. The decrease in left FPN connectivity during the early abstinence period in AUD may reflect an initially upregulated FPN, which recovers to a lower resting-state connectivity level during subsequent weeks of abstinence. The AUD patients showed a trend for a positive association between the change in left FPN connectivity and trait anxiety (rs = 0.303, p = 0.068), and a trend for a negative association between the change in left FPN connectivity and delay discounting (rs = −0.283, p = 0.089) (uncorrected for multiple comparisons). This suggests that the FPN might be involved in top-down control of impulsivity and anxiety, which are important risk factors for relapse. Although there were no statistically significant results (after multiple comparison correction), our preliminary findings encourage further research into the dynamic neuroadaptations during the clinically crucial early abstinence period and could inform future study designs.
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影响因子：
4.7
作者：
Yang X;Meng YJ;Tao YJ;Deng RH;Wang HY;Li XJ;Wei W;Hua Y;Wang Q;Deng W;Zhao LS;Ma XH;Li ML;Xu JJ;Li J;Liu YS;Tang Z;Du XD;Coid JW;Greenshaw AJ;Li T;Guo WJ
通讯作者：
Guo WJ
影响因子：
4.2
作者：
Compton WM;Dawson DA;Goldstein RB;Grant BF
通讯作者：
Grant BF
影响因子：
3.4
作者：
Durazzo TC;Mon A;Gazdzinski S;Yeh PH;Meyerhoff DJ
通讯作者：
Meyerhoff DJ
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
3.7
作者：
Buhle, Jason T.;Silvers, Jennifer A.;Ochsner, Kevin N.
通讯作者：
Ochsner, Kevin N.