Functional Connectivity of Nucleus Accumbens and Medial Prefrontal Cortex With Other Brain Regions During Early-Abstinence Is Associated With Alcohol Dependence and Relapse: A Resting-Functional Magnetic Resonance Imaging Study.
Functional Connectivity of Nucleus Accumbens and Medial Prefrontal Cortex With Other Brain Regions During Early-Abstinence Is Associated With Alcohol Dependence and Relapse: A Resting-Functional Magnetic Resonance Imaging Study.
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DOI：
10.3389/fpsyt.2021.609458
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发表时间：
2021
影响因子：
4.7
通讯作者：
Guo WJ
中科院分区：
文献类型：
--
作者：
Yang X;Meng YJ;Tao YJ;Deng RH;Wang HY;Li XJ;Wei W;Hua Y;Wang Q;Deng W;Zhao LS;Ma XH;Li ML;Xu JJ;Li J;Liu YS;Tang Z;Du XD;Coid JW;Greenshaw AJ;Li T;Guo WJ
背景资料：酒精依赖（AD）是一种慢性复发性脑部疾病，在世界范围内造成沉重的疾病负担，部分原因是戒毒后复发率高。尽管中脑核（NAc）和内侧前额叶皮层（mPFC）可能在成瘾机制中起重要作用，但尚未发现AD及其复发的生物标志物。本研究调查了早期戒断期间NAc和mPFC与其他脑区的AD和复发相关功能连接（FC）。研究方法：68例住院早期禁欲AD男性患者和68例年龄和教育程度匹配的健康对照（HC）进行静息功能磁共振成像（r-fMRI）。使用NAc和mPFC作为种子，我们计算了种子和其他大脑区域之间的FC变化。在6个月的随访期内，使用酒精使用障碍识别测试（AUDIT）量表对患者进行测量，以确定复发结局（AUDIT ≥ 8）。结果：35例（52.24%）AD患者在随访期间复发。与对照组相比，AD显示左侧梭状、双侧颞上级和右侧中央后区与NAc的FC较低，右侧颞下、双侧颞上级和左侧扣带前部与mPFC的FC较低。在这些FC变化中，NAc和左侧梭状核之间的FC降低，mPFC和左侧扣带前皮质之间的FC降低，以及吸烟状态与AD独立相关。与非复发受试者相比，复发受试者的右侧扣带前皮质与NAc和左侧距状沟与mPFC的FC较低; FC的这两种降低独立预测复发。此外，mPFC和右额上级回之间的FC，以及多年的教育，独立预测复发的严重程度。结论：本研究发现，所选种子之间的FC值（即，NAc和mPFC）和其他一些奖励和/或冲动控制相关的脑区与AD和复发相关;这些FC值可能是AD的潜在生物标志物或用于预测复发。这些发现可能有助于指导进一步研究AD和其他成瘾性疾病的神经生物学。
Background: Alcohol dependence (AD) is a chronic recurrent brain disease that causes a heavy disease burden worldwide, partly due to high relapse rates after detoxification. Verified biomarkers are not available for AD and its relapse, although the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) may play important roles in the mechanism of addiction. This study investigated AD- and relapse-associated functional connectivity (FC) of the NAc and mPFC with other brain regions during early abstinence. Methods: Sixty-eight hospitalized early-abstinence AD male patients and 68 age- and education-matched healthy controls (HCs) underwent resting-functional magnetic resonance imaging (r-fMRI). Using the NAc and mPFC as seeds, we calculated changes in FC between the seeds and other brain regions. Over a follow-up period of 6 months, patients were measured with the Alcohol Use Disorder Identification Test (AUDIT) scale to identify relapse outcomes (AUDIT ≥ 8). Results: Thirty-five (52.24%) of the AD patients relapsed during the follow-up period. AD displayed lower FC of the left fusiform, bilateral temporal superior and right postcentral regions with the NAc and lower FC of the right temporal inferior, bilateral temporal superior, and left cingulate anterior regions with the mPFC compared to controls. Among these FC changes, lower FC between the NAc and left fusiform, lower FC between the mPFC and left cingulate anterior cortex, and smoking status were independently associated with AD. Subjects in relapse exhibited lower FC of the right cingulate anterior cortex with NAc and of the left calcarine sulcus with mPFC compared to non-relapsed subjects; both of these reductions in FC independently predicted relapse. Additionally, FC between the mPFC and right frontal superior gyrus, as well as years of education, independently predicted relapse severity. Conclusion: This study found that values of FC between selected seeds (i.e., the NAc and the mPFC) and some other reward- and/or impulse-control-related brain regions were associated with AD and relapse; these FC values could be potential biomarkers of AD or for prediction of relapse. These findings may help to guide further research on the neurobiology of AD and other addictive disorders.
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影响因子：
4.2
作者：
Becker, Jill B.;McClellan, Michele L.;Reed, Beth Glover
通讯作者：
Reed, Beth Glover
影响因子：
4.2
作者：
Hanlon, Colleen A.;Dowdle, Logan T.;Naselaris, Thomas;Canterberry, Melanie;Cortese, Bernadette M.
通讯作者：
Cortese, Bernadette M.
影响因子：
7.7
作者：
Ewing, Samuel G.;Grace, Anthony A.
通讯作者：
Grace, Anthony A.
DOI：
10.1111/add.12876
发表时间：
2015-05
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Cheng HG;Deng F;Xiong W;Phillips MR
通讯作者：
Phillips MR
影响因子：
3.9
作者：
Bottlender, M;Soyka, M
通讯作者：
Soyka, M