Imaging acute effects of bevacizumab on tumor vascular kinetics in a preclinical orthotopic model of U251 glioma.
Imaging acute effects of bevacizumab on tumor vascular kinetics in a preclinical orthotopic model of U251 glioma.
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DOI：
10.1002/nbm.4516
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发表时间：
2021-07
影响因子：
2.9
通讯作者：
Ewing JR
中科院分区：
文献类型：
--
作者：
Nagaraja TN;Elmghirbi R;Brown SL;Rey JA;Schultz L;Mukherjee A;Cabral G;Panda S;Lee IY;Sarntinoranont M;Keenan KA;Knight RA;Ewing JR
研究了人血管内皮生长因子抗体对大鼠脑内生长的人肿瘤血管系统的影响。在原位U251胶质母细胞瘤（GBM）大鼠模型中，使用动态对比增强磁共振成像，在给药前和给药后1、2、4、8、12和24 h（N = 26;每个时间点4-5）检查静脉注射贝伐珠单抗（安维汀; 10 mg/kg）的作用。MR造影剂的常用估计血管参数为：（i）血浆分布体积（vp），（ii）正向体积传输常数（Ktranss）和（iii）反向传输常数（kep）。此外，估计肿瘤（VD-肿瘤）、肿瘤边缘（VD-边缘）和大部分正常肿瘤周边（VD-边缘）中的细胞外分布体积（VD），沿着肿瘤血流量（TBF）、肿瘤周围的水力传导率（K）和间质流量（Flux）和肿瘤间质流体压力（TIFP）。以相对于基线的%变化进行研究，治疗后2小时时间点开始显示vp、VD-肿瘤、VD-边缘和VD-边缘以及K显著降低，其中vp、K、VD-肿瘤、VD-边缘和VD-边缘的这些变化在4小时和8小时持续（t检验; p < 0.05-0.01）。在2小时和4小时时间点观察到Ktranss减少（p < 0.05），而间质体积分数（ve; = Ktranss/kep）仅在2小时时间点显示出显著减少（p < 0.05）。从2 ~ 24 h观察到通量持续下降（p < 0.01），而TBF和TIFP显示延迟反应，前者在12和24 h增加，后者仅在12 h减少。这些肿瘤血管动力学的成像生物标志物描述了安维汀给药后GBM模型中物理空间和液体流动的短期时间变化。
The effect of a human vascular endothelial growth factor antibody on the vasculature of human tumor grown in rat brain was studied. Using dynamic contrast-enhanced magnetic resonance imaging, the effects of intravenous bevacizumab (Avastin; 10 mg/kg) were examined before and at postadministration times of 1, 2, 4, 8, 12 and 24 h (N = 26; 4–5 per time point) in a rat model of orthotopic, U251 glioblastoma (GBM). The commonly estimated vascular parameters for an MR contrast agent were: (i) plasma distribution volume (vp), (ii) forward volumetric transfer constant (Ktrans) and (iii) reverse transfer constant (kep). In addition, extracellular distribution volume (VD) was estimated in the tumor (VD-tumor), tumor edge (VD-edge) and the mostly normal tumor periphery (VD-peri), along with tumor blood flow (TBF), peri-tumoral hydraulic conductivity (K) and interstitial flow (Flux) and tumor interstitial fluid pressure (TIFP). Studied as % changes from baseline, the 2-h post-treatment time point began showing significant decreases in vp, VD-tumor, VD-edge and VD-peri, as well as K, with these changes persisting at 4 and 8 h in vp, K, VD-tumor, -edge and -peri (t-tests; p < 0.05–0.01). Decreases in Ktrans were observed at the 2- and 4-h time points (p < 0.05), while interstitial volume fraction (ve; = Ktrans/kep) showed a significant decrease only at the 2-h time point (p < 0.05). Sustained decreases in Flux were observed from 2 to 24 h (p < 0.01) while TBF and TIFP showed delayed responses, increases in the former at 12 and 24 h and a decrease in the latter only at 12 h. These imaging biomarkers of tumor vascular kinetics describe the short-term temporal changes in physical spaces and fluid flows in a model of GBM after Avastin administration.
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影响因子：
2.9
作者：
Ewing JR;Nagaraja TN;Aryal MP;Keenan KA;Elmghirbi R;Bagher-Ebadian H;Panda S;Lu M;Mikkelsen T;Cabral G;Brown SL
通讯作者：
Brown SL
影响因子：
3.3
作者：
Aryal, Madhava P.;Nagaraja, Tavarekere N.;Keenan, Kelly A.;Bagher-Ebadian, Hassan;Panda, Swayamprava;Brown, Stephen L.;Cabral, Glauber;Fenstermacher, Joseph D.;Ewing, James R.
通讯作者：
Ewing, James R.
DOI：
10.1002/jmri.24469
发表时间：
2014-11
期刊：
Journal of magnetic resonance imaging : JMRI
影响因子：
--
作者：
Chwang WB;Jain R;Bagher-Ebadian H;Nejad-Davarani SP;Iskander AS;VanSlooten A;Schultz L;Arbab AS;Ewing JR
通讯作者：
Ewing JR
影响因子：
14
作者：
Ananthanarayanan, Badriprasad;Kim, Yushan;Kumar, Sanjay
通讯作者：
Kumar, Sanjay
影响因子：
3.3
作者：
Bagher-Ebadian, Hassan;Jain, Rajan;Nejad-Davarani, Siamak P.;Mikkelsen, Tom;Lu, Mei;Jiang, Quan;Scarpace, Lisa;Arbab, Ali S.;Narang, Jayant;Soltanian-Zadeh, Hamid;Paudyal, Ramesh;Ewing, James. R.
通讯作者：
Ewing, James. R.