TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling.
TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling.
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DOI：
10.3389/fimmu.2012.00076
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发表时间：
2012
影响因子：
7.3
通讯作者：
Reinherz EL
中科院分区：
文献类型：
--
作者：
Kim ST;Shin Y;Brazin K;Mallis RJ;Sun ZY;Wagner G;Lang MJ;Reinherz EL
机械转导是许多生物系统中受体信号传导的基础。基于光钳实验的最新数据表明，TCR是一种各向异性机械传感器，在特定肽-MHC复合物（pMHC）连接时将机械能转化为生化信号。沿连接后TCR复合物的伪二重对称轴线施加的切向力沿着导致αβ异二聚体由于T细胞-APC界面处的分子运动而对CD 3异二聚体施加扭矩。伴随的TCR四元变化可能通过基于TCR-pMHC力的大小和方向的脂质双层促进信号传导。TCR聚糖可以调节四级变化，从而改变信号传导结果，如位于异源二聚体CD 3亚基中TM区段附近的CxxC基序的氧化还原状态。预测的TCR TM区段和周围脂质的改变将胞外域连接转化为最早的胞内信号传导事件。
Mechanotransduction is a basis for receptor signaling in many biological systems. Recent data based upon optical tweezer experiments suggest that the TCR is an anisotropic mechanosensor, converting mechanical energy into biochemical signals upon specific peptide-MHC complex (pMHC) ligation. Tangential force applied along the pseudo-twofold symmetry axis of the TCR complex post-ligation results in the αβ heterodimer exerting torque on the CD3 heterodimers as a consequence of molecular movement at the T cell–APC interface. Accompanying TCR quaternary change likely fosters signaling via the lipid bilayer predicated on the magnitude and direction of the TCR–pMHC force. TCR glycans may modulate quaternary change, thereby altering signaling outcome as might the redox state of the CxxC motifs located proximal to the TM segments in the heterodimeric CD3 subunits. Predicted alterations in TCR TM segments and surrounding lipid will convert ectodomain ligation into the earliest intracellular signaling events.
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影响因子：
32.4
作者：
Adams JJ;Narayanan S;Liu B;Birnbaum ME;Kruse AC;Bowerman NA;Chen W;Levin AM;Connolly JM;Zhu C;Kranz DM;Garcia KC
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作者：
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作者：
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通讯作者：
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影响因子：
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作者：
Bäckström, BT;Müller, U;Palmer, E
通讯作者：
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