Planning and real-time monitoring of low intensity focused ultrasound therapies using a diagnostic imaging array
Planning and real-time monitoring of low intensity focused ultrasound therapies using a diagnostic imaging array
复制标题
使用诊断成像阵列规划和实时监测低强度聚焦超声治疗
DOI：
10.1117/12.2580943
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
M. Oelze
中科院分区：
文献类型：
--
作者：
M. Thies;M. Oelze
在这项工作中，提出了一个系统，用于组合治疗计划，低强度FUS治疗，并使用一个单一的诊断成像阵列的实时治疗监测。首先，通过从用成像阵列捕获的B模式图像手动分割治疗区域来确定超声处理模式。为了使FUS治疗束可视化，发射聚焦脉冲激励，并且使用反向散射信号来重建FUS束的强度场。将FUS射束重建叠加到用成像阵列捕获的共对准B模式图像上，从而允许利用来自B模式图像的解剖背景定性地监测FUS射束的位置和大小。在大鼠体内肿瘤中实现了帧速率为25-30帧/秒的实时束可视化，并在组织模拟中计划和监测模拟FUS治疗。
In this work, a system is presented for combined therapy planning, low intensity FUS treatment, and real-time therapy monitoring using a single diagnostic imaging array. First, a sonication pattern was determined by manually segmenting the treatment region from a B-mode image captured with the imaging array. To visualize the FUS therapy beam, a focused pulse excitation was transmitted and backscattered signals were used to reconstruct the intensity field of the FUS beam. The FUS beam reconstruction was overlaid onto a co-aligned B-mode image captured with the imaging array, allowing one to qualitatively monitor the position and size of the FUS beam with anatomical context from the B-mode image. Real-time beam visualizations at a frame rate of 25-30 frames per second were achieved in a rat tumor in vivo and a mock FUS therapy was planned and monitored in a tissue-mimicking.
影响因子：
2.4
作者：
Salgaonkar, Vasant A.;Datta, Saurabh;Mast, T. Douglas
通讯作者：
Mast, T. Douglas
影响因子：
10.5
作者：
Jolesz FA
通讯作者：
Jolesz FA
影响因子：
2.9
作者：
Vaezy, S;Shi, XG;Crum, LA
通讯作者：
Crum, LA