Azithromycin decreases crevicular fluid volume and mediator content.
Azithromycin decreases crevicular fluid volume and mediator content.
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DOI：
10.1177/0022034510368650
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发表时间：
2010-08
影响因子：
7.6
通讯作者：
Walters J
中科院分区：
文献类型：
--
作者：
Ho W;Eubank T;Leblebicioglu B;Marsh C;Walters J
阿奇霉素在治疗慢性肺部疾病中增强对根面平整的反应并产生抗炎作用。这使我们假设阿奇霉素抑制牙龈中炎症介质的产生，导致龈沟液（GCF）量减少。为了验证这一假设，10名牙周健康的志愿者每24小时接受阿奇霉素治疗48小时。在阿奇霉素给药前（基线）和给药后2、4、7和14天，从12个上颌邻间部位采集GCF样本。测定样品的IL-1β、IL-8、TNF-α、VEGF、IL-6和IL-10。阿奇霉素治疗后，GCF体积在第2天至第7天显著降低（P < 0.05），但在第14天增加至基线水平。IL-1β、IL-8、TNF-α和VEGF含量均呈一过性下降（P < 0.05）。IL-6和IL-10未检出。由于在整个研究中没有牙菌斑，研究结果表明阿奇霉素在牙龈中产生抗炎作用。
Azithromycin enhances the response to root planing and produces anti-inflammatory effects in treating chronic lung disease. This led us to hypothesize that azithromycin inhibits inflammatory mediator production in gingiva, leading to decreased gingival crevicular fluid (GCF) volume. To test this hypothesis, ten periodontally healthy volunteers received azithromycin every 24 hours for 48 hours. GCF samples were collected from twelve maxillary interproximal sites prior to azithromycin (baseline) and 2, 4, 7 and 14 days later. Samples were assayed for IL-1β, IL-8, TNF-α, VEGF, IL-6 and IL-10. With azithromycin treatment, GCF volume decreased significantly on days 2 through 7 (P < 0.05), but increased toward baseline levels on day 14. This was accompanied by a transient decrease in the content of IL-1β, IL-8, TNF-α and VEGF (P < 0.05). IL-6 and IL-10 were not detected. Since plaque was absent throughout the study, the findings suggest that azithromycin produces anti-inflammatory effects in gingiva.
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影响因子：
4.3
作者：
Mascarenhas, P;Gapski, R;Wang, HL
通讯作者：
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影响因子：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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影响因子：
4.3
作者：
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通讯作者：
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